LTF

Gene Symbol LTF
Entrez Gene 4057
Alt Symbol GIG12, HEL110, HLF2, LF
Species Human
Gene Type protein-coding
Description lactotransferrin
Other Description epididymis luminal protein 110|growth-inhibiting protein 12|kaliocin-1|lactoferricin|lactoferroxin|neutrophil lactoferrin|talalactoferrin
Swissprots O00756 Q96KZ4 Q8IU92 Q16789 Q9UCY5 Q96KZ5 P02788 Q8TCD2 E7EQH5 Q5DSM0 Q9H1Z3 Q8IZH6 Q16785 Q16786 A8K9U8 B2MV13 Q16780 B7Z4X2
Accessions AAA59479 AAB24877 AAB57795 AAN84790 AAO14686 ACC95966 ACC95967 EAW64767 P02788 AF332168 AAG48753 AK093852 BAG52774 AK290859 BAF83548 AK292813 BAF85502 AK298035 BAH12708 AK303889 BAG64824 AK303995 BAG64912 AK316330 BAH14701 AY137470 AAN11304 AY165046 AAN63998 AY178998 AAN75578 AY360320 AAR12276 AY493417 AAS72878 AY875691 AAW71443 BC015822 AAH15822 BC015823 AAH15823 BC022347 AAH22347 BP342557 CD722125 DQ522304 ABF69105 DQ892855 ABM83781 DQ896102 ABM87101 EU779935 ACF19793 EU794669 ACJ13723 KF992208 AHL67504 M18642 AAA86665 M83202 AAA59511 M83205 AAA58656 M93150 AAA36159 U07643 AAB60324 U84119 X52941 CAA37116 X53961 CAA37914 NM_001199149 NP_001186078 NM_002343 NP_002334
Function Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.
Subcellular Location Isoform 1: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.
Tissue Specificity High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex. {ECO:0000269|PubMed:10792619, ECO:0000269|PubMed:2981589, ECO:0000269|PubMed:9122171}.

LTF-Over-expression-Lysate - LY12918a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag LTF (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LTF gene

Human Lactotransferrin / LTF HEK293 Cell Lysate (WB positive control) - 11096-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Lactoferrin Overexpression Lysate (Native) - NBP2-10824 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Lactoferrin Overexpression Lysate (Adult Normal) [NBP2-10824] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Lactoferrin.

Human LTF Human Cells Transfected Lysate (positive control) (denatured) - orb173869 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human LTF Knockdown Stable Cell Line - CSC-DC008986 from Creative biogene

Category Cell Line
Species Human
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