Nampt

Gene Symbol	Nampt
Entrez Gene	59027
Alt Symbol	1110035O14Rik, AI314458, AI480535, NAmPRTase, Pbef, Pbef1, Visfatin
Species	Mouse
Gene Type	protein-coding
Description	nicotinamide phosphoribosyltransferase
Other Description	pre-B-cell colony-enhancing factor 1 homolog
Swissprots	Q99KQ4 Q8C3B5 Q9JKM0
Accessions	EDL36889 Q99KQ4 AF234625 AAF43208 AK004117 AK086415 BAC39664 AK153926 AK166270 BAE38671 AY679720 AAT72933 BC004059 AAH04059 BC018358 AAH18358 BY068469 CV561474 NM_021524 NP_067499
Function	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD- dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000269|PubMed:12555668, ECO:0000269|PubMed:15381699, ECO:0000269|PubMed:19286518, ECO:0000269|PubMed:19299583}.
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:P43490}. Cytoplasm {ECO:0000269|PubMed:12555668}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
Tissue Specificity	Ubiquitously expressed in lymphoid and non- lymphoid tissues. {ECO:0000269|PubMed:12555668}.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Recombinant Mouse PBEF/Visfatin/NAMPT Protein - NBC1-22597 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli

Recombinant Mouse PBEF/Visfatin/NAMPT Protein - NBC1-18474 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli

PBEF/Visfatin/NAMPT Recombinant Protein - P4531 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Mouse

PBEF/Visfatin/NAMPT Protein - NBP1-99183 from Novus Biologicals Category Protein Species Mouse

PBEF/Visfatin/NAMPT Protein - NBP1-99619 from Novus Biologicals Category Protein Prices $469.00 Sizes 50 µg Species Mouse

PBEF/Visfatin/NAMPT Recombinant Protein - P4328 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Species Mouse

Visfatin recombinant protein - GTX65440 from GeneTex Category Protein Prices $249.00 Sizes 10 μg Source E. coli Species Mouse

Visfatin recombinant protein - GTX65439 from GeneTex Category Protein Prices $419.00 Sizes 50 μg Source E. coli Species Mouse

Visfatin Protein (OPPA00706) - OPPA00706 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Visfatin protein (His tag) - 80R-1028 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

Visfatin / NAMPT (His-tag) - AR09097PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Mouse

Visfatin / NAMPT (His-tag) - AR09097PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Mouse

Visfatin / NAMPT - P4328 from Acris Antibodies Category Protein Prices $580.00 Sizes 100 µg Species Mouse

Visfatin / NAMPT - P4531 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Mouse

Visfatin, Mouse Recombinant - 228-11638-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Mouse

Recombinant Mouse Visfatin - 228-11638-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Mouse

Recombinant Mouse Visfatin - 228-11638-3 from RayBiotech Category Protein Source Escherichia Coli. Species Mouse

Visfatin (VF), Mouse - 20-6927 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Mouse

Visfatin, 1- 491aa, Mouse, His-tagged, Recombinant, E.coli - 01-2298M from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Source E.coli Species Mouse

Visfatin Mouse - CYPS-454 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Mouse

Recombinant Mouse Visfatin - BP000130-CYT-447 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Mouse

Visfatin, 1- 491aa, Recombinant Protein - GWB-P0008H from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Mouse

Recombinant Mouse Nicotinamide Phosphoribosyltransferase - Nampt-1667M from Creative Biomart Category Protein Source E. coli Species Mouse

Recombinant Mouse Nampt, FLAG-tagged - Nampt-422M from Creative Biomart Category Protein Source HEK293 Cells Species Mouse

Recombinant Mouse Pre-B-cell Colony-enhancing Factor 1, His-tagged - Nampt-157M from Creative Biomart Category Protein

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