Nampt
| Gene Symbol | Nampt |
|---|---|
| Entrez Gene | 59027 |
| Alt Symbol | 1110035O14Rik, AI314458, AI480535, NAmPRTase, Pbef, Pbef1, Visfatin |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | nicotinamide phosphoribosyltransferase |
| Other Description | pre-B-cell colony-enhancing factor 1 homolog |
| Swissprots | Q99KQ4 Q8C3B5 Q9JKM0 |
| Accessions | EDL36889 Q99KQ4 AF234625 AAF43208 AK004117 AK086415 BAC39664 AK153926 AK166270 BAE38671 AY679720 AAT72933 BC004059 AAH04059 BC018358 AAH18358 BY068469 CV561474 NM_021524 NP_067499 |
| Function | The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD- dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000269|PubMed:12555668, ECO:0000269|PubMed:15381699, ECO:0000269|PubMed:19286518, ECO:0000269|PubMed:19299583}. |
| Subcellular Location | Nucleus {ECO:0000250|UniProtKB:P43490}. Cytoplasm {ECO:0000269|PubMed:12555668}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}. |
| Tissue Specificity | Ubiquitously expressed in lymphoid and non- lymphoid tissues. {ECO:0000269|PubMed:12555668}. |
| Top Pathways | Nicotinate and nicotinamide metabolism |
Visfatin antibody - 20R-1862 from Fitzgerald
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Visfatin / NAMPT antibody - PAB9553 from Acris Antibodies
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Anti-Visfatin Antibody - AC16-0041 from Abcore
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Anti-Visfatin Antibody (AMCA) - AC16-0041-01 from Abcore
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Anti-Visfatin Antibody (AP) - AC16-0041-02 from Abcore
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Anti-Visfatin Antibody (APC) - AC16-0041-03 from Abcore
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Anti-Visfatin Antibody (APC-Cy5.5) - AC16-0041-04 from Abcore
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Anti-Visfatin Antibody (APC-Cy7) - AC16-0041-05 from Abcore
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Anti-Visfatin Antibody (Avidin) - AC16-0041-06 from Abcore
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Anti-Visfatin Antibody (Biotin) - AC16-0041-07 from Abcore
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Anti-Visfatin Antibody (BPE) - AC16-0041-08 from Abcore
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Anti-Visfatin Antibody (Cy3) - AC16-0041-09 from Abcore
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Anti-Visfatin Antibody (Cy5) - AC16-0041-10 from Abcore
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Anti-Visfatin Antibody (Cy5.5) - AC16-0041-11 from Abcore
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Anti-Visfatin Antibody (FITC) - AC16-0041-12 from Abcore
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Anti-Visfatin Antibody (Glucose Oxidase) - AC16-0041-13 from Abcore
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Anti-Visfatin Antibody (HRP) - AC16-0041-14 from Abcore
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Anti-Visfatin Antibody (PE-Cy5) - AC16-0041-15 from Abcore
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Anti-Visfatin Antibody (PE-Cy5.5) - AC16-0041-16 from Abcore
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Anti-Visfatin Antibody (PE-Cy7) - AC16-0041-17 from Abcore
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Anti-Visfatin Antibody (PerCP) - AC16-0041-18 from Abcore
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Anti-Visfatin Antibody (PerCP-Cy5.5) - AC16-0041-19 from Abcore
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Anti-Visfatin Antibody (Rhodamine) - AC16-0041-20 from Abcore
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Anti-Visfatin Antibody (RPE) - AC16-0041-21 from Abcore
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Anti-Visfatin Antibody (Streptavidin) - AC16-0041-22 from Abcore
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