TNFSF13B

Gene Symbol	TNFSF13B
Entrez Gene	10673
Alt Symbol	BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 13b
Other Description	ApoL related ligand TALL-1|B-cell-activating factor|B-lymphocyte stimulator|Delta4 BAFF|TNF and ApoL-related leukocyte expressed ligand 1|TNF homolog that activates apoptosis|delta BAFF|dendritic cell-derived TNF-like molecule|tumor necrosis factor (ligand) superfamily, member 20|tumor necrosis factor ligand superfamily member 13B|tumor necrosis factor-like protein ZTNF4
Swissprots	Q9Y275 Q6FHD6 Q7Z5J2 E0ADT7
Accessions	ABK41889 BAB90856 EAX09099 EAX09100 EAX09101 Q9Y275 AF116456 AAD25356 AF132600 AAD21092 AF134715 AAF60219 AF136293 AAD29421 AF186114 AAF01432 AK309629 AW151367 AW963062 AY129225 AAN08421 AY129226 AAN08422 AY129227 AAN08423 AY129228 AAN08424 AY302751 AAP83164 AY358881 AAQ89240 BC020674 AAH20674 BI818459 BQ776352 BQ778438 BX482686 CR541818 CAG46617 D79690 DQ857728 DQ891413 ABM82339 EU176634 ABW03435 HM636064 ADK91575 XM_005254029 XP_005254086 NM_001145645 NP_001139117 NM_006573 NP_006564
Function	Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}.
Top Pathways	Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BAFF full length protein - ab167731 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human BAFF full length protein - ab79745 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source E. coli Species Human

Active human BAFF full length protein - ab198426 from Abcam Category Protein Prices $3,317.00 Sizes 100 µg Source E. coli Species Human

Active human BAFF full length protein - ab192127 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active human BAFF full length protein - ab109136 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source E. coli Species Human

Active human BAFF protein fragment - ab50087 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Active mouse BAFF full length protein - ab157285 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source HEK 293 cells Species Mouse

BAFF peptide - ab8397 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Chicken BAFF protein fragment - ab177578 from Abcam Category Protein Prices $100.00 Sizes 5 µg Source Yeast Species Chicken

Cow BAFF full length protein - ab169713 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Yeast Species Bovine

Dog BAFF full length protein - ab169715 from Abcam Category Protein Prices $235.00 Sizes 25 µg Source Yeast Species Dog

Horse BAFF protein fragment - ab189226 from Abcam Category Protein Prices $368.00 Sizes 25 µg Source Yeast Species Horse

Human BAFF full length protein - ab78840 from Abcam Category Protein Prices $196.00 Sizes 50 µg Source E. coli Species Human

Human BAFF full length protein - ab155638 from Abcam Category Protein Prices $456.00 Sizes 100 µg Source HEK 293 cells Species Human

Human BAFF full length protein - ab193869 from Abcam Category Protein Prices $176.00 Sizes 4 µg Source Mammalian Species Human

Human BAFF peptide - ab69714 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Mouse BAFF full length protein - ab136355 from Abcam Category Protein Source Yeast Species Mouse

Pig BAFF protein fragment - ab177575 from Abcam Category Protein Source Yeast Species Pig

BAFF Antibody Blocking Peptide - LS-E2872 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAFF Antibody Blocking Peptide - LS-E21422 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAFF Antibody Blocking Peptide - LS-E29917 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human BAFF/BLyS/TNFSF13B Protein - NBP2-34883 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

BAFF/BLyS/TNFSF13B Protein - NBC1-22600 from Novus Biologicals Category Protein Prices $369.00 Sizes 100 µg Species Human

Recombinant Human BAFF/BLyS/TNFSF13B Protein - NBC1-18481 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

Recombinant Human BAFF/BLyS/TNFSF13B Protein - H00010673-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Search more