| Gene Symbol | a |
|---|---|
| Entrez Gene | 50518 |
| Alt Symbol | A<y>, ASIP, ASP, As |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | nonagouti |
| Other Description | agouti coat color protein|agouti signal protein|agouti switch protein|agouti-signaling protein|non-agouti |
| Swissprots | A2ALT3 Q03288 Q80ST0 |
| Accessions | EDL06104 EDL06105 EDL06106 Q03288 AK156952 AK172452 BC009122 L06451 AAA37201 L06452 L06941 S63413 AAA15908 S70320 AAP19635 S70326 AAP19636 S70394 AAP19637 S74479 AAP31517 S74489 AAP31519 S74493 AAP31520 XM_011239689 XP_011237991 XM_011239690 XP_011237992 XM_011239691 XP_011237993 XM_011251809 XP_011250111 XM_011251810 XP_011250112 XR_375144 XR_375145 XR_375146 XR_375149 XR_400376 XR_400377 XR_400378 XR_400381 XR_866315 XR_866316 XR_866317 XR_866319 XR_866320 XR_866321 XR_866322 XR_886317 XR_886318 XR_886319 XR_886320 XR_886321 XR_886322 XR_886323 NM_015770 NP_056585 |
| Function | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Epithelial cells of the hair follicles and the epidermis. |
| Top Pathways | Melanogenesis |
Recombinant Mouse a, His-tagged - a-3242M from Creative Biomart
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Recombinant Mouse Agouti-signaling protein(Asip) - CSB-YP002212MO CSB-EP002212MO CSB-BP002212MO CSB-MP002212MO from Cusabio
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Agouti-signaling protein (Asip) - MBS956999 from MyBioSource
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Recombinant Mouse ASIP/Agouti Protein, CF - 9619-AG from R&D Systems
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