Gene Symbol | TTC19 |
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Entrez Gene | 54902 |
Alt Symbol | 2010204O13Rik, MC3DN2 |
Species | Human |
Gene Type | protein-coding |
Description | tetratricopeptide repeat domain 19 |
Other Description | TPR repeat protein 19|tetratricopeptide repeat protein 19, mitochondrial |
Swissprots | Q9NXB2 A8MZ52 Q9H6G3 Q7L3U8 B4DN65 B3KP62 Q2M248 Q6DKK2 |
Accessions | EAX04490 EAX04491 Q6DKK2 AK000350 BAA91103 AK025958 BAB15296 AK055780 BAG51574 AK056878 BAG51820 AK094819 BAG52935 AK297783 BAG60127 AL832412 AW083291 BC003058 BC011698 AAH11698 BC073796 AAH73796 BC105128 AAI05129 BC112107 AAI12108 CA417932 XM_011523950 XP_011522252 NM_001271420 NP_001258349 NM_017775 NP_060245 |
Function | Mitochondrial protein required for formation of the mitochondrial complex III (PubMed:21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed:20208530). However, the involvement in cytokinesis requires additional experimental evidence. {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:21278747}. |
Subcellular Location | Mitochondrion inner membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=According to some authors, localizes to the centrosome during all stages of the cell cycle and is recruited to the midbody during cytokinesis (PubMed:20208530). However, the midbody localization could not be confirmed by others (PubMed:21278747). {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:21278747}. |
TTC19 CRISPR/Cas9 KO Plasmid (h) - sc-412375 from Santa Cruz Biotechnology
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TTC19 HDR Plasmid (h) - sc-412375-HDR from Santa Cruz Biotechnology
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TTC19 Double Nickase Plasmid (h) - sc-412375-NIC from Santa Cruz Biotechnology
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TTC19 Double Nickase Plasmid (h2) - sc-412375-NIC-2 from Santa Cruz Biotechnology
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TTC19 CRISPR Activation Plasmid (h) - sc-412375-ACT from Santa Cruz Biotechnology
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TTC19 CRISPR Activation Plasmid (h2) - sc-412375-ACT-2 from Santa Cruz Biotechnology
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TTC19 Lentiviral Activation Particles (h) - sc-412375-LAC from Santa Cruz Biotechnology
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TTC19 Lentiviral Activation Particles (h2) - sc-412375-LAC-2 from Santa Cruz Biotechnology
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TTC19 siRNA (h) - sc-94186 from Santa Cruz Biotechnology
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TTC19 shRNA Plasmid (h) - sc-94186-SH from Santa Cruz Biotechnology
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TTC19 shRNA (h) Lentiviral Particles - sc-94186-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU022771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22156 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22156 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08627 from Sigma-Aldrich
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TTC19 siRNA (Human) - CRJ0311 from Cohesion Biosciences
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TTC19 - MBS8239219 from MyBioSource
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shRNA set against Human TTC19 (NM_017775.3) - SHH436844 from Creative biogene
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TTC19 shRNA Plasmid (Human) - CHJ0311 from Cohesion Biosciences
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TTC19 miRNA 3'UTR clone - MiUTR3H-13043 from Creative biogene
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