POLR3D

Gene Symbol	POLR3D
Entrez Gene	661
Alt Symbol	BN51T, RPC4, RPC53, TSBN51
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Other Description	BN51 (BHK21) temperature sensitivity complementing|DNA-directed RNA polymerase III 47 kDa polypeptide|DNA-directed RNA polymerase III subunit D|DNA-directed RNA polymerase III subunit RPC4|RNA polymerase III 47 kDa subunit|RNA polymerase III subunit C4|RPC53 homolog|temperature sensitive complementation, cell cycle specific, tsBN51
Swissprots	Q9BPV7 Q9BXB3 Q6FI28 P05423 Q9BPZ1
Accessions	AAA72377 AAD29429 EAW63689 EAW63690 EAW63691 EAW63692 P05423 AF346574 AAK15371 AK026588 AK125346 AK295725 BAG58566 AY092086 AAM18216 BC000516 BC002603 AAH02603 BC003039 BC004484 AAH04484 BQ006609 BX537545 CR536509 CAG38747 CR541803 CAG46602 HQ447310 ADQ31797 M17754 AAA51838 XM_011544629 XP_011542931 XR_949463 NM_001722 NP_001713
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLR3D full length protein - ab157971 from Abcam Category Protein Source Wheat germ Species Human

Human POLR3D protein fragment - ab114942 from Abcam Category Protein Source Wheat germ Species Human

POLR3D Antibody Blocking Peptide - LS-E2472 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human POLR3D Protein - H00000661-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human POLR3D Protein - H00000661-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

POLR3D-Antibody-Center-Blocking-peptide - BP13498c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLR3D - H00000661-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

POLR3D - H00000661-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POLR3D - H00000661-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POLR3D fusion protein - Ag7646 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

POLR3D fusion protein - Ag7542 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human POLR3D - POLR3D-30686TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human POLR3D, His-tagged - POLR3D-1850H from Creative Biomart Category Protein Source E.coli Species Human

POLR3D (N314) Peptide - BS3854P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA-directed RNA polymerase III subunit RPC4(POLR3D) - CSB-YP018346HU CSB-EP018346HU CSB-BP018346HU CSB-MP018346HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR3D - TP302505 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

POLR3D Recombinant Protein Antigen - NBP2-49556PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

POLR3D Recombinant Protein Antigen - NBP2-49530PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

POLR3D Peptide, Human - M34GP12107H from Creative Peptides Category Peptide Source Synthetic. Species Human

POLR3D Recombinant Protein Antigen - NBP2-55887PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA-directed RNA polymerase III subunit RPC4 (POLR3D), Recombinant Protein - MBS965802 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,875.00, $1,875.00, $2,340.00, $2,340.00 Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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