Gene Symbol | HTR3E |
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Entrez Gene | 285242 |
Alt Symbol | 5-HT3-E, 5-HT3E, 5-HT3c1 |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic |
Other Description | 5-hydroxytryptamine (serotonin) receptor 3, family member E|5-hydroxytryptamine receptor 3 subunit E|5-hydroxytryptamine receptor 3E |
Swissprots | Q6V706 Q6V707 E9PGF1 A8IKD7 Q7Z6B2 Q495G3 A5X5Y0 Q495G1 |
Accessions | A5X5Y0 EAW78304 AY159813 AAO38167 AY349352 AAQ93476 AY349353 AAQ93477 BC101182 AAI01183 BC101183 AAI01184 BC101184 BC101185 AAI01186 DQ644022 ABG35128 EU165354 ABW05298 NM_001256613 NP_001243542 NM_001256614 NP_001243543 NM_182589 NP_872395 NM_198313 NP_938055 NM_198314 NP_938056 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:19012743}; Multi-pass membrane protein {ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:19012743}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
Tissue Specificity | Expressed in adult colon and intestine. {ECO:0000269|PubMed:12801637, ECO:0000269|PubMed:14597179}. |
HTR3E CRISPR/Cas9 KO Plasmid (h) - sc-418317 from Santa Cruz Biotechnology
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HTR3E HDR Plasmid (h) - sc-418317-HDR from Santa Cruz Biotechnology
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HTR3E Double Nickase Plasmid (h) - sc-418317-NIC from Santa Cruz Biotechnology
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HTR3E Double Nickase Plasmid (h2) - sc-418317-NIC-2 from Santa Cruz Biotechnology
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HTR3E CRISPR Activation Plasmid (h) - sc-418317-ACT from Santa Cruz Biotechnology
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HTR3E CRISPR Activation Plasmid (h2) - sc-418317-ACT-2 from Santa Cruz Biotechnology
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HTR3E Lentiviral Activation Particles (h) - sc-418317-LAC from Santa Cruz Biotechnology
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HTR3E Lentiviral Activation Particles (h2) - sc-418317-LAC-2 from Santa Cruz Biotechnology
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HTR3E siRNA (h) - sc-78474 from Santa Cruz Biotechnology
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HTR3E shRNA Plasmid (h) - sc-78474-SH from Santa Cruz Biotechnology
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HTR3E shRNA (h) Lentiviral Particles - sc-78474-V from Santa Cruz Biotechnology
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5-HT3E RNAi - H00285242-R01 from Novus Biologicals
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MISSION® esiRNA - EHU010061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10397 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10397 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02056 from Sigma-Aldrich
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HTR3E siRNA (Human) - CRJ7080 from Cohesion Biosciences
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HTR3E - MBS8221713 from MyBioSource
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shRNA set against Human HTR3E (NM_182589.2) - SHH315981 from Creative biogene
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Human HTR3E siRNA - orb277581 from Biorbyt
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HTR3E shRNA Plasmid (Human) - CHJ7080 from Cohesion Biosciences
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HTR3E miRNA 3'UTR clone - MiUTR1H-04757 from Creative biogene
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