OTUB1

Gene Symbol	OTUB1
Entrez Gene	55611
Alt Symbol	HSPC263, OTB1, OTU1
Species	Human
Gene Type	protein-coding
Description	OTU deubiquitinase, ubiquitin aldehyde binding 1
Other Description	OTU domain, ubiquitin aldehyde binding 1|OTU domain-containing ubiquitin aldehyde-binding protein 1|OTU-domain Ubal-binding 1|deubiquitinating enzyme OTUB1|otubain-1|ubiquitin thioesterase OTUB1|ubiquitin-specific protease otubain 1|ubiquitin-specific-processing protease OTUB1
Swissprots	Q9P0B8 Q32Q78 Q96FW1 Q9NXQ4 Q96II3
Accessions	CAH05305 EAW74187 EAW74188 EAW74189 EAW74190 EAW74191 Q96FW1 AF161381 AAF28941 AK000120 BAA90956 AK091830 AK098029 BAG53567 AK225133 AK298287 BAG60547 AK303228 BAG64315 AK307413 AL096714 CAH56412 AY177200 AAO27702 BC007519 AAH07519 BC010368 AAH10368 BC107701 AAI07702 CK906312 NM_017670 NP_060140 NR_003089
Function	Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OTUB1 full length protein - ab157086 from Abcam Category Protein Source E. coli Species Human

Human OTUB1 full length protein - ab87682 from Abcam Category Protein Source E. coli Species Human

OTUB1 / OTU1 Antibody Blocking Peptide - LS-E20777 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OTUB1 / OTU1 Antibody Blocking Peptide - LS-E20776 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OTUB1 / OTU1 Antibody Blocking Peptide - LS-E26763 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Otubain-1 Recombinant Protein - H00055611-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Otubain-1 Protein - NBP1-30186 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Recombinant Human Otubain-1 Protein - NBP1-99514 from Novus Biologicals Category Protein Prices $265.00 Sizes 50 µg Source E. coli Species Human

OTUB1 blocking peptide - GTX88681-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

Recombinant Human His6-Otubain-1, CF - E-522B-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant human Ubiquitin thioesterase OTUB1 (OPCA00517) - OPCA00517 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

OTUB1 Protein (OPPA02162) - OPPA02162 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human FLJ20113 protein - orb245183 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Deubiquitinating enzyme OTUB1 protein - orb84538 from Biorbyt Category Protein Prices $315.00, $357.00 Sizes 50 μg, 100 μg Source E. coli Species Human

OTUB1 Blocking Peptide - 33R-4432 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

OTUB1 Blocking Peptide - 33R-2145 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Otubain 1 protein (His tag) - 80R-1172 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Human Otubain 1 Protein - abx068407 from Abbexa Category Protein Source E.coli Species Human

OTUB1 Peptide - AC21-1598-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Otubain-1 (OTUB1) (1-271, His-tag) - AR09235PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Otubain-1 (OTUB1) (1-271, His-tag) - AR09235PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Otubain-1 (OTUB1) - H00055611-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Otubain-1 (OTUB1) - H00055611-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Ubiquitin Aldehyde Binding 1, Human Recombinant - 228-11183-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human OTUB1 - 228-11183-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

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