| Gene Symbol | OTUB1 |
|---|---|
| Entrez Gene | 55611 |
| Alt Symbol | HSPC263, OTB1, OTU1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | OTU deubiquitinase, ubiquitin aldehyde binding 1 |
| Other Description | OTU domain, ubiquitin aldehyde binding 1|OTU domain-containing ubiquitin aldehyde-binding protein 1|OTU-domain Ubal-binding 1|deubiquitinating enzyme OTUB1|otubain-1|ubiquitin thioesterase OTUB1|ubiquitin-specific protease otubain 1|ubiquitin-specific-processing protease OTUB1 |
| Swissprots | Q9P0B8 Q32Q78 Q96FW1 Q9NXQ4 Q96II3 |
| Accessions | CAH05305 EAW74187 EAW74188 EAW74189 EAW74190 EAW74191 Q96FW1 AF161381 AAF28941 AK000120 BAA90956 AK091830 AK098029 BAG53567 AK225133 AK298287 BAG60547 AK303228 BAG64315 AK307413 AL096714 CAH56412 AY177200 AAO27702 BC007519 AAH07519 BC010368 AAH10368 BC107701 AAI07702 CK906312 NM_017670 NP_060140 NR_003089 |
| Function | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020}. |