CD101
| Gene Symbol | CD101 |
|---|---|
| Entrez Gene | 9398 |
| Alt Symbol | EWI-101, IGSF2, V7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD101 molecule |
| Other Description | cell surface glycoprotein V7|glu-Trp-Ile EWI motif-containing protein 101|immunoglobulin superfamily member 2|leukocyte surface protein |
| Swissprots | Q93033 Q15856 |
| Accessions | EAW56664 EAW56665 Q93033 AI791963 AK298237 BAG60504 AK307542 BC130327 AAI30328 BC136484 AAI36485 BC171768 AAI71768 BP300139 DA582363 DA955029 Z33642 CAA83923 XR_946802 NM_001256106 NP_001243035 NM_001256109 NP_001243038 NM_001256111 NP_001243040 NM_004258 NP_004249 |
| Function | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. {ECO:0000269|PubMed:10692025, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:7722300, ECO:0000269|PubMed:9389317}. |
CD101 CRISPR/Cas9 KO Plasmid (h) - sc-417728 from Santa Cruz Biotechnology
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CD101 HDR Plasmid (h) - sc-417728-HDR from Santa Cruz Biotechnology
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CD101 Double Nickase Plasmid (h) - sc-417728-NIC from Santa Cruz Biotechnology
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CD101 Double Nickase Plasmid (h2) - sc-417728-NIC-2 from Santa Cruz Biotechnology
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CD101 CRISPR Activation Plasmid (h) - sc-417728-ACT from Santa Cruz Biotechnology
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CD101 CRISPR Activation Plasmid (h2) - sc-417728-ACT-2 from Santa Cruz Biotechnology
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CD101 Lentiviral Activation Particles (h) - sc-417728-LAC from Santa Cruz Biotechnology
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CD101 Lentiviral Activation Particles (h2) - sc-417728-LAC-2 from Santa Cruz Biotechnology
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CD101 siRNA (h) - sc-42819 from Santa Cruz Biotechnology
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CD101 shRNA Plasmid (h) - sc-42819-SH from Santa Cruz Biotechnology
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CD101 shRNA (h) Lentiviral Particles - sc-42819-V from Santa Cruz Biotechnology
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IGSF2/CD101 RNAi - H00009398-R01 from Novus Biologicals
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MISSION® esiRNA - EHU042311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5677 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5677 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01004 from Sigma-Aldrich
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CD101 siRNA (Human) - CRH6228 from Cohesion Biosciences
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CD101 - MBS8241130 from MyBioSource
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shRNA set against Human CD101 (NM_004258.4) - SHH258441 from Creative biogene
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Human CD101 siRNA - orb266730 from Biorbyt
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CD101 shRNA Plasmid (Human) - CHH6228 from Cohesion Biosciences
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CD101 miRNA 3'UTR clone - MiUTR3H-06881 from Creative biogene
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