| Gene Symbol |
CD101
|
| Entrez Gene |
9398
|
| Alt Symbol |
EWI-101, IGSF2, V7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD101 molecule
|
| Other Description |
cell surface glycoprotein V7|glu-Trp-Ile EWI motif-containing protein 101|immunoglobulin superfamily member 2|leukocyte surface protein
|
| Swissprots |
Q93033 Q15856
|
| Accessions |
EAW56664 EAW56665 Q93033 AI791963 AK298237 BAG60504 AK307542 BC130327 AAI30328 BC136484 AAI36485 BC171768 AAI71768 BP300139 DA582363 DA955029 Z33642 CAA83923 XR_946802 NM_001256106 NP_001243035 NM_001256109 NP_001243038 NM_001256111 NP_001243040 NM_004258 NP_004249
|
| Function |
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. {ECO:0000269|PubMed:10692025, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:7722300, ECO:0000269|PubMed:9389317}.
|