Gene Symbol | DNMT1 |
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Entrez Gene | 1786 |
Alt Symbol | ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT |
Species | Human |
Gene Type | protein-coding |
Description | DNA (cytosine-5-)-methyltransferase 1 |
Other Description | CXXC-type zinc finger protein 9|DNA (cytosine-5)-methyltransferase 1|DNA MTase HsaI|DNA methyltransferase HsaI|m.HsaI |
Swissprots | P26358 A0AV63 Q9ULA2 Q9UHG5 B7ZLW6 Q9UMZ6 |
Accessions | AAD54507 EAW84079 EAW84080 P26358 AB209413 BAD92650 AF180682 AAF23609 AF290894 AK122759 BAG53712 AY927518 BC092517 AAH92517 BC126227 AAI26228 BC144093 AAI44094 DA653750 X63692 CAA45219 XM_011527772 XP_011526074 XM_011527773 XP_011526075 XM_011527774 XP_011526076 NM_001130823 NP_001124295 NM_001379 NP_001370 |
Function | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12145218}. |
Tissue Specificity | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. {ECO:0000269|PubMed:10325416}. |
Top Pathways | Cysteine and methionine metabolism, MicroRNAs in cancer |
DNMT1 (D63A6) XP ® Rabbit mAb - 5032 from Cell Signaling Technology
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DNMT1 (D59A4) Rabbit mAb - 5119 from Cell Signaling Technology
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Dnmt1 (H-12) - sc-271729 from Santa Cruz Biotechnology
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Dnmt1 (H-300) - sc-20701 from Santa Cruz Biotechnology
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Dnmt1 (K-18) - sc-10221 from Santa Cruz Biotechnology
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Dnmt1 (C-17) - sc-10222 from Santa Cruz Biotechnology
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Dnmt1 (N-16) - sc-10219 from Santa Cruz Biotechnology
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Dnmt1 (18) - sc-135887 from Santa Cruz Biotechnology
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p-Dnmt1 (Ser 714) - sc-130595 from Santa Cruz Biotechnology
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p-Dnmt1 (Tyr 399) - sc-130596 from Santa Cruz Biotechnology
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p-Dnmt1 (Tyr 969) - sc-130597 from Santa Cruz Biotechnology
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Anti-Dnmt1 antibody - ab19905 from Abcam
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Anti-Dnmt1 antibody - ab87654 from Abcam
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Anti-Dnmt1 antibody - ab2849 from Abcam
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Anti-Dnmt1 antibody - ab11892 from Abcam
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Anti-Dnmt1 antibody - ab45281 from Abcam
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Anti-Dnmt1 antibody [2B5] - ab54759 from Abcam
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Anti-Dnmt1 antibody [60B12201] - ChIP Grade - ab176145 from Abcam
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Anti-Dnmt1 antibody [7C11A2] - C-terminal - ab181462 from Abcam
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Anti-Dnmt1 antibody [EPR3521(2)] - ab134148 from Abcam
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Anti-Dnmt1 antibody [EPR3521(2)] (Alexa Fluor® 488) - ab197272 from Abcam
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Anti-Dnmt1 antibody [EPR3521(2)] (HRP) - ab196927 from Abcam
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Anti-Dnmt1 antibody [EPR3522] - ab92314 from Abcam
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Anti-Dnmt1 antibody - ChIP Grade - ab87656 from Abcam
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Anti-Dnmt1 antibody - N-terminal - ab152153 from Abcam
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