DES

Gene Symbol DES
Entrez Gene 1674
Alt Symbol CSM1, CSM2, LGMD2R
Species Human
Gene Type protein-coding
Description desmin
Other Description intermediate filament protein|mutant desmin p.K241E
Swissprots P17661 Q549R8 Q8IZR1 Q9UJ80 Q8TCX2 Q8NES2 Q549R7 Q9UHN5 Q8TAC4 Q8IZR6 Q15787 Q549R9 Q8TD99 Q8NEU6
Accessions AAA99221 AAG43459 AAG43460 AAM47026 AAV64888 AAV64889 AAV64890 AAY15051 ABC33803 AGC00770 CAA37307 EAW70739 EAW70740 EAW70741 P17661 AF055081 AAC39938 AF055082 AAC39939 AF055083 AAC39940 AF137053 AAF15400 AF167579 AAG41217 AF486807 AAL93205 AF487828 AAL99078 AF521879 AAN15036 AF527578 AAN37810 AJ132926 CAB62389 AK022087 AK097038 AK098332 AK123787 AK300654 BAG62342 AL541778 AY083345 AAL99215 AY125465 AAM95238 BC010072 BC032116 AAH32116 BQ941246 DQ104335 AAZ17411 DQ104336 AAZ17412 DQ104337 AAZ17413 DQ892282 ABM83208 DQ895482 ABM86408 EF617312 ABR08708 JX114780 AGC00771 U59167 AAC50680 NM_001927 NP_001918
Function Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Subcellular Location Cytoplasm.
Top Pathways Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Desmin (D93F5) XP ® Rabbit mAb - 5332 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D93F5
Western blot analysis of extracts from C2C12 cells, rat heart and human heart using Desmin (D93F5) XP ® Rabbit mAb.

Desmin Antibody - 4024 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse heart, rat heart and C2C12 cells using Desmin Antibody.

Desmin (B-12) - sc-365130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Desmin (B-12): sc-365130. Western blot analysis of Desmin expression in Sol8 (A) and SJRH30 (B) whole cell lysates.

Desmin (B-7) - sc-271677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Desmin (B-7): sc-271677. Western blot analysis of Desmin expression in SJRH30 whole cell lysate.

Desmin (A-18) - sc-34200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Desmin (A-18): sc-34200. Western blot analysis of Desmin expression in non-transfected 293T: sc-117752 (A), mouse Desmin transfected 293T: sc-119754 (B) and SJRH30 (C) whole cell lysates.

Desmin (10H7D2) - sc-65983 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Desmin (10H7D2): sc-65983. Western blot analysis of Desmin expression in non-transfected 293T: sc-117752 (A), mouse Desmin transfected 293T: sc-119754 (B) and SJRH30 (C) whole cell lysates.

Desmin (H-76) - sc-14026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Desmin (H-76): sc-14026. Western blot analysis of Desmin expression in SJRH30 whole cell lysate.

Desmin (E-20) - sc-34201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Desmin (E-20): sc-34201. Western blot analysis of Desmin expression in non-transfected: sc-117752 (A) and mouse Desmin transfected: sc-119754 (B) 293T whole cell lysates.

Desmin (RD301) - sc-23879 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Desmin (RD301): sc-23879. Immunofluorescence staining of methanol-fixed SJRH30 cells showing cytoplasmic localization.

Desmin (Y-20) - sc-7559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Desmin (Y-20): sc-7559. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma showing cytoskeletal localization (A). Immunofluorescence staining of methanol-fixed Sol8 cells showing cytoplasmic localization (B).

Desmin (DE-R-11) - sc-58745 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl supernatant
Host Mouse
Clonality Monoclonal
Desmin (DE-R-11): sc-58745. Western blot analysis of Desmin expression in non-transfected 293T: sc-117752 (A), mouse Desmin transfected 293T: sc-119754 (B) and SJRH30 (C) whole cell lysates.

Desmin (D9) - sc-52326 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Desmin (D9): sc-52326. Western blot analysis of Desmin expression in SJRH30 whole cell lysate.

Desmin (D33) - sc-58744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
Desmin (D33): sc-58744. Western blot analysis of Desmin expression in non-transfected 293T: sc-117752 (A), mouse Desmin transfected 293T: sc-119754 (B) and SJRH30 (C) whole cell lysates.

Desmin (4A45) - sc-70961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Desmin (4A45): sc-70961. Western blot analysis of Desmin expression in non-transfected 293T: sc-117752 (A), mouse Desmin transfected 293T: sc-119754 (B) and SJRH30 (C) whole cell lysates.

p-Desmin (Thr 16) - sc-130593 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Desmin (phospho S60) antibody - ab111382 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111382 at 1/50 dilution staining Desmin in paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-Desmin antibody - ab15200 from Abcam

Prices $403.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab15200 staining Desmin in Mouse skin tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 5% serum for 1 hour at room temperature; antigen retrieval was enzymatic. Samples were incubated with primary antibody (1/800 in blocking buffer) for 16 hours at 4°C. An undiluted HRP-conjugated Horse anti-rabbit IgG polyclonal was used as the secondary antibody.See Abreview

Anti-Desmin antibody - ab8592 from Abcam

Prices $401.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab8592 staining Desmin in mouse pericytes (xenograft tumor tissue) by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with formaldehyde and blocked with 1% BSA for 30 minutes at 25°C. Samples were incubated with primary antibody (1/400 in PBS + goat serum) for 18 hours at 4°C. An Alexa Fluor® 555-conjugated pig anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.See Abreview

Anti-Desmin antibody - ab64969 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Desmin antibody (ab64969) at 1/500 dilutionLane 1 : HeLa cell extract; without immunizing peptideLane 2 : HepG2 cell extract; without immunizing peptide Lane 3 : HepG2 cell extract; with immunizing peptide

Anti-Desmin antibody - ab52240 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Desmin antibody (ab52240) at 1/300 dilutionLane 1 : K562 cell extract; without peptideLane 2 : K562 cell extract; with peptide

Anti-Desmin antibody [D33] - ab8470 from Abcam

Prices $379.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone D33
IHC image of ab8470 staining in human skeletal muscle formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab8470, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Desmin antibody, prediluted - ab15201 from Abcam

Prices $378.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15201 staining Desmin in human leiomyosarcoma by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-Desmin antibody [Y66] - Cytoskeleton Marker - ab32362 from Abcam

Prices $404.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y66
All lanes : Anti-Desmin antibody [Y66] - Cytoskeleton Marker (ab32362) at 1/500000 dilution (purified)Lane 1 : Human skeletal muscle tissue lysateLane 2 : Human fetal heart tissue lysateLane 3 : Human fetal muscle tissue lysateLysates/proteins at 20 µg per lane.SecondaryHRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG at 1/1000 dilution

Anti-Desmin antibody [Y66] - Cytoskeleton Marker (Alexa Fluor® 488) - ab185033 from Abcam

Prices $439.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y66
Overlay histogram showing SV40LT-SMC cells stained with ab185033 (red line). The cells were fixed with 4% formaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab185033, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Desmin antibody [Y66] - Cytoskeleton Marker (HRP) - ab195178 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y66
IHC image of Desmin staining in a section of formalin-fixed paraffin-embedded normal human skeletal muscle*, performed on a Leica BOND. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab195178 at 1/70 dilution, for 15 mins at room temperature. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.*Tissue obtained from the Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre
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