Gene Symbol | HLA-DRB1 |
---|---|
Entrez Gene | 3123 |
Alt Symbol | DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1 |
Species | Human |
Gene Type | protein-coding |
Description | major histocompatibility complex, class II, DR beta 1 |
Other Description | DW2.2/DR2.2|HLA class II histocompatibility antigen, DR-1 beta chain|MHC class II HLA-DR beta 1 chain|MHC class II HLA-DR-beta cell surface glycoprotein|MHC class II HLA-DRw10-beta|MHC class II antigen|human leucocyte antigen DRB1|lymphocyte antigen DRB1 |
Swissprots | Q6T865 Q3KTM1 Q32MY7 Q29790 P01911 Q29974 Q56FN9 Q30166 O98212 Q5Y7B9 Q30142 Q29792 A7X5J4 Q3LA84 Q0PGR5 Q29975 Q3HUP9 Q95383 P01912 Q5Y7B0 Q30200 Q30120 Q30159 Q30167 P01914 Q9MYF5 Q30134 O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37 Q9UIM9 P20039 Q30006 Q9GIX8 P13761 B0UYW1 O46699 O46872 Q9GIY3 A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6 A7X5H8 A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4 B9X248 O02876 O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770 Q29772 Q29800 Q2A120 Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90 Q3LA91 Q3LA92 Q3T919 Q4PRC3 Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5 Q860D8 Q860D9 Q860S0 Q861H5 Q861H7 Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5 Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57 Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7 Q95IE3 A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6 Q5NDB9 Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40 Q9TQE0 Q30149 P04229 A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461 Q9BCL7 Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91 Q5Y7A7 A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2 B5A8Y3 B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6 Q29673 Q29720 Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95 Q3LA96 Q3LA97 Q3LA98 Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2 Q5UBA2 Q5W3L4 Q6REE2 Q6U387 Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3 Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0 Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60 Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3 Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453 P13760 O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5 |
Accessions | AAA03142 AAA35775 AAA35776 AAA36273 AAA36284 AAA36290 AAA36298 AAA51400 AAA52321 AAA52324 AAA53101 AAA53102 AAA53174 AAA53186 AAA58652 AAA59481 AAA59689 AAA59713 AAA59779 AAA59789 AAA59790 AAA59798 AAA59808 AAA59817 AAA62591 AAA67123 AAA67958 AAA67990 AAA72783 AAA74994 AAA75372 AAA75387 AAA79784 AAA79830 AAA87226 AAA91837 AAA91839 AAA91842 AAA91844 AAA91845 AAA91846 AAA91986 AAA93191 AAA93192 AAA96820 AAA99889 AAB05219 AAB06950 AAB08761 AAB48012 AAB59623 AAB63317 AAB63320 AAB70217 AAB92519 AAB94613 AAC05182 AAC05276 AAC41708 AAC41709 AAD03597 AAD14052 AAD16437 AAD24059 AAD29581 AAD29584 AAD31287 AAD31288 AAD31290 AAD31291 AAD31293 AAD31294 AAD31296 AAD31297 AAD31298 AAD31299 AAD31300 AAD31301 AAD31302 AAD31303 AAD31304 AAD31305 AAD31306 AAD31307 AAD31308 AAD31311 AAD31312 AAD31313 AAD38374 AAD45284 AAD51314 AAD51316 AAD51969 AAD51970 AAF03162 AAF08286 AAF32310 AAF43716 AAF59946 AAF65475 AAF65476 AAF65477 AAF65478 AAF65479 AAF65480 AAF65481 AAF65482 AAF65483 AAF65484 AAF65485 AAF65486 AAF65487 AAF65488 AAF65498 AAF65499 AAF65501 AAF65542 AAF73947 AAF82750 AAF87751 AAG00413 AAG12983 AAG17449 AAG22827 AAK01305 AAK07657 AAK08492 AAK08493 AAK08504 AAK20873 AAK20874 AAK27708 AAK27709 AAK27710 AAK27711 AAK27713 AAK30584 AAK51524 AAK51525 AAK54252 AAK61607 AAK67648 AAK85431 AAK94509 AAK96249 AAL23552 AAL23553 AAL35224 AAL35834 AAL40075 AAL47162 AAL92173 AAM09473 AAM09543 AAM14400 AAM18713 AAM75383 AAN38832 AAO17052 AAO17053 AAO17055 AAO18733 AAO21195 AAO23240 AAO23241 AAO39066 AAO49837 AAO67518 AAP06242 AAP21611 AAP21813 AAP23231 AAP34690 AAP34692 AAP34693 AAP55806 AAP57472 AAQ14285 AAR10878 AAR10883 AAR21104 AAR29079 AAR98642 AAR98645 AAR98646 AAR98758 AAS19443 AAS47492 AAT46361 AAT72340 AAU44812 AAU87979 AAU87993 AAU88003 AAU88005 AAU88008 AAU88014 AAU88018 AAU88023 AAU88029 AAU88033 AAU88035 AAV33674 AAV33679 AAV52249 AAW47394 AAW57989 AAX47961 AAX51706 AAY17287 AAY17288 AAY40253 AAY43234 AAY59543 AAZ16488 AAZ41844 AAZ41845 AAZ42160 ABA06594 ABA06598 ABA06599 ABA06601 ABA28306 ABA39176 ABB52004 ABB91804 ABC59115 ABC61957 ABD60301 ABF18976 ABF60564 ABF60566 ABF74596 ABF74597 ABF74598 ABG42995 ABG56235 ABG91053 ABH03635 ABH05926 ABK56695 ABK56698 ABK56700 ABK63713 ABK96990 ABL98033 ABM45857 ABO69630 ABP01682 ABP68560 ABP68561 ABR08292 ABS87340 ABS87341 ABS87342 ABS87344 ABS87346 ABS87347 ABS87348 ABS87349 ABT17103 ABT17104 ABT17105 ABU50754 ABU50755 ABU50756 ABU50758 ABU50759 ABU50760 ABU50761 ABU50764 ABU50767 ABU50768 ABU86859 ABU86860 ABU86861 ABU86863 ABV48914 ABV66221 ABY26527 ABY81285 ABY81286 ABY81287 ACA28738 ACB20697 ACD01091 ACD01093 ACD40041 ACE00043 ACE00044 ACE00045 ACE00046 ACE63270 ACE63272 ACE88696 ACE88699 ACE88703 ACE88705 ACF36164 ACH57405 ACI12830 ACI12831 ACI12847 ACI12851 ACI12852 ACI26728 ACJ06537 ACJ71263 ACJ71265 ACJ71266 ACJ71267 ACJ71268 ACJ71269 ACJ71270 ACJ71271 ACJ71272 ACJ71273 ACJ71274 ACJ71275 ACJ71276 ACJ71277 ACJ71278 ACJ71279 ACJ71280 ACJ71281 ACJ71282 ACJ71283 ACL34374 ACL51034 ACL51035 ACL80124 ACN56341 ACN56342 ACN56345 ACN81299 ACN81301 ACN81304 ACN81310 ACO25411 ACO25418 ACO25419 ACO50427 ACO58645 ACO87689 ACO87690 ACO87691 ACO87692 ACO87693 ACO87694 ACO87695 ACO87696 ACO87697 ACO87698 ACO87699 ACO87700 ACO87701 ACO87702 ACO87703 ACO87704 ACO87705 ACO87706 ACO87707 ACO87708 ACO87709 ACO87710 ACO87711 ACO87712 ACO87713 ACO90088 ACO90093 ACO90094 ACP27926 ACP27927 ACP27930 ACP27931 ACP31208 ACP40977 ACQ99529 ACR25204 ACR61333 ACS15383 ACT83727 ACT83729 ACU00006 ACU00008 ACU00011 ACU02223 ACU02225 ACU27323 ACU46610 ACU46611 ACU46612 ACU46614 ACU46616 ACU65235 ACV30338 ACV31954 ACV31956 ACV31957 ACV31959 ACV31960 ACV31961 ACV40750 ACV40752 ACV51797 ACV89485 ACV89488 ACV89489 ACX35431 ACX42679 ACX81410 ACX81417 ACY06697 ACY09074 ACY09076 ACY09078 ACY09079 ACY09080 ACY09087 ADB55623 ADB80062 ADB80063 ADB80064 ADC32270 ADC32271 ADC45489 ADC79889 ADD71852 ADD71853 ADD97673 ADD97875 ADD97877 ADE58756 ADE58761 ADE58763 ADE58764 ADE58766 ADE58767 ADE58769 ADE58770 ADE58775 ADE58776 ADE58777 ADE58778 ADE73002 ADE73096 ADE73097 ADE73098 ADE73099 ADE73190 ADE73258 ADE73260 ADE73341 ADE73426 ADE73427 ADE73428 ADE73429 ADE73430 ADE73431 ADE73432 ADE73433 ADE73436 ADE73438 ADE73481 ADE73482 ADE73538 ADE73589 ADE73645 ADE73646 ADE73647 ADE73648 ADE73649 ADE73650 ADE73651 ADE73652 ADE73653 ADE73723 ADE73724 ADE73725 ADE73728 ADF58795 ADI24367 ADI75487 ADJ67221 ADJ67229 ADJ67232 ADM72793 ADN92677 ADN92678 ADT80798 ADU18510 ADU78720 ADV78575 ADV78576 ADV78591 ADX31869 ADZ05574 ADZ05575 ADZ05576 ADZ05580 ADZ05582 ADZ05584 ADZ05585 ADZ05588 ADZ05591 ADZ05592 ADZ05593 ADZ05595 ADZ05597 ADZ05601 ADZ05602 ADZ05603 ADZ05604 ADZ05605 ADZ05607 ADZ05611 ADZ05613 ADZ05614 ADZ05615 ADZ05616 ADZ05617 ADZ73161 ADZ73164 ADZ73165 ADZ73167 ADZ74184 AEA49848 AEA49851 AEA49852 AEA49853 AEA49855 AEA49856 AEA49857 AEA49861 AEA49865 AEA49866 AEA49867 AEA51189 AEB21071 AEB21072 AEB21073 AEB21075 AEB21076 AEB21078 AEB21079 AEB21080 AEB21081 AEB21082 AEB21083 AEB52319 AEB65787 AEB65801 AEB65803 AEF13148 AEF13155 AEF13156 AEF13157 AEF13967 AEF13968 AEF13975 AEF13976 AEH95528 AEI01082 AEI01083 AEI30830 AEI30831 AEI30832 AEI59615 AEI59617 AEI59619 AEI59620 AEI59622 AEI59624 AEI59625 AEI59631 AEI59633 AEI59634 AEI59635 AEI59637 AEI59639 AEI59640 AEI59641 AEI59643 AEI59644 AEI59650 AEI59651 AEI59652 AEI87651 AEI87653 AEI87655 AEJ08640 AEJ22089 AEJ22091 AEJ87208 AEJ87322 AEJ90530 AEJ90533 AEJ90534 AEJ90535 AEJ90537 AEJ90538 AEK27140 AEK27141 AEK67352 AEK94848 AEK94849 AEK94850 AEK94856 AEK94864 AEK94866 AEK94867 AEK94868 AEK94869 AEK94870 AEK94964 AEK94965 AEK94967 AEK94968 AEK94969 AEK94970 AEK94971 AEK94972 AEK94999 AEK95000 AEK95004 AEK95097 AEK95098 AEK95101 AEK95219 AEK95220 AEK95221 AEK95222 AEK95223 AEK95224 AEK95225 AEK95226 AEK95227 AEK95228 AEK95229 AEK95230 AEK95231 AEK95232 AEK95233 AEK95234 AEK95235 AEK95236 AEK95237 AEK95238 AEK95239 AEK95240 AEK95241 AEK95242 AEK95243 AEK95250 AEK95252 AEK95253 AEK95255 AEK95256 AEK95264 AEK95267 AEK95268 AEK95269 AEK95272 AEK95274 AEK95276 AEK95278 AEK95281 AEK95282 AEK95283 AEK95284 AEK95285 AEK95286 AEK95287 AEK95288 AEK95335 AEK95380 AEK95382 AEK95383 AEK95384 AEK95385 AEK95386 AEK95387 AEQ28186 AEQ28187 AEQ28189 AER92539 AER92550 AEU10128 AEU10155 AEU10156 AEU10158 AEU10163 AEU10164 AEU10185 AEV76919 AEV76920 AEV76921 AEV76924 AEV76925 AEV91335 AEW23002 AEW23003 AEW23004 AEW23006 AEW23111 AEW23112 AEW23113 AEW23114 AEW23115 AEW23116 AEW23117 AEW23118 AEW23119 AEW23120 AEW23121 AEW23122 AEW90707 AEW90708 AEW90711 AEW90712 AEW90713 AEW90714 AEY68571 AEY78616 AEY80128 AEY80130 AFA42494 AFA42495 AFA42616 AFA42620 AFA42691 AFA42695 AFA42736 AFA42775 AFA42776 AFA42779 AFA42780 AFA42781 AFA42782 AFA42783 AFA42784 AFA42785 AFA42786 AFA42787 AFA42788 AFA42789 AFA42790 AFA42791 AFA42792 AFA42793 AFA42794 AFA42795 AFA42796 AFA42797 AFA42798 AFB74728 AFE88962 AFK49808 AFN52224 AFN61283 AFN61289 AFN70959 AFN88141 AFN88143 AFO64625 AFO66761 AFO66762 AFP43732 AFQ62771 AFQ62772 AFQ62774 AFQ62775 AFQ62776 AFQ90236 AFQ90237 AFS35466 AFT82611 AFU93111 AFU93119 AFU93120 AFU93121 AFU93122 AFU93123 AFU93124 AFU93125 AFU93126 AFU93127 AFU93128 AFU93129 AFU93130 AFU93131 AFU93132 AFU93135 AFU93136 AFU93137 AFU93138 AFU93139 AFU93140 AFU93141 AFU93142 AFU93834 AFV74669 AFX62410 AFX62411 AFZ94253 AFZ94254 AFZ94256 AFZ94257 AFZ94258 AFZ94259 AFZ94260 AFZ94261 AFZ94262 AFZ94263 AFZ94264 AFZ94265 AFZ94266 AFZ94267 AFZ94268 AFZ94269 AFZ94270 AFZ94271 AFZ94272 AFZ94273 AFZ94275 AFZ94277 AFZ94278 AFZ94279 AFZ94280 AFZ94281 AFZ94282 AFZ94291 AFZ94296 AFZ94299 AFZ94310 AFZ94311 AFZ94313 AFZ94314 AFZ94315 AFZ94316 AFZ94317 AFZ94318 AFZ94323 AFZ94327 AFZ94328 AFZ94329 AFZ94330 AFZ94332 AFZ94333 AFZ94334 AFZ94335 AFZ94336 AFZ94337 AFZ94338 AFZ94339 AFZ94340 AFZ94341 AFZ94345 AFZ94346 AFZ94348 AFZ94350 AFZ94351 AFZ94354 AFZ94358 AFZ94361 AFZ94365 AFZ94369 AFZ94370 AFZ94371 AFZ94372 AFZ94373 AFZ94374 AFZ94375 AFZ94376 AFZ94449 AFZ94451 AFZ94477 AFZ94481 AFZ94483 AFZ94572 AFZ94573 AFZ94574 AFZ94575 AFZ94577 AFZ94578 AFZ94580 AFZ94611 AFZ94614 AFZ94615 AFZ94628 AGB06229 AGB06230 AGB06231 AGB75974 AGC54629 AGE97349 AGE97350 AGF39093 AGF39094 AGF39096 AGG68133 AGG68846 AGG68851 AGG68852 AGG79718 AGG79719 AGG79720 AGG79735 AGG79768 AGG79770 AGG79801 AGG79885 AGG79923 AGG79953 AGG79956 AGG79985 AGH25580 AGI48721 AGI48725 AGI48726 AGJ84107 AGJ84108 AGJ84110 AGK07579 AGK44339 AGK44340 AGK44343 AGK44353 AGK44354 AGL09220 AGL09221 AGL09223 AGL73166 AGL93382 AGL93383 AGM53428 AGO03661 AGO03666 AGS55365 AGS55366 AGS55367 AGS55368 AGS55369 AGS55370 AGS55371 AGS55372 AGT79680 AGU13641 AGW50699 AGW50700 AGW50701 AGW50702 AGW50703 AGW50704 AGW50705 AGW50706 AGW50707 AGW50708 AGW50709 AGW50710 AGW50711 AGX13908 AGX13910 AHA90860 AHA93559 AHF71357 AHF71358 AHF71360 AHF71361 AHG52869 AHG55091 AHL17463 AHY18666 AHY61347 AHY61348 AHY61349 AHY61350 AHY61351 AHY61352 AHY61353 AHY61354 AHY61355 AHY61356 AHY61357 AHY61358 AHY61359 AHY61365 AHY61367 AHY61369 AHY61370 AHY61372 AHY61373 AHY61374 AHY61375 AHY61376 AHY61377 AHY61378 AHY61379 AHY61380 AHY61381 AHY61382 AHY61383 AHY61384 AHY61386 AHY61387 AHY61388 AHY61389 AHY61390 AHY61394 AHY61395 AHY61397 AHY61398 AHY61400 AHY61404 AHY61405 AHY61407 AHY61408 AHY61411 AHY61412 AHY61413 AHY61418 AHY61419 AHY61420 AHY61422 AHY61423 AHY61424 AHY61426 AHY61427 AHY61428 AHY61429 AHY61430 AHY61431 AHY61438 AHY61439 AHY61440 AHY61449 AHY82354 AHY82357 AHY82358 AHY82363 AHY82365 AHY82368 AHY82370 AHY82372 AHY82373 AHY82374 AHY82375 AHY82376 AHY82379 AHY82380 AHY82382 AHY82383 AHY82384 AHY82386 AHY82388 AHY82389 AHY82392 AHY82393 AHZ31158 AHZ31159 AHZ31165 AHZ31166 AHZ31167 AHZ31169 AHZ31172 AHZ31175 AHZ31176 AHZ31179 AHZ31183 AHZ31184 AHZ31185 AHZ31196 AHZ31197 AHZ31198 AHZ31199 AHZ31200 AHZ31201 AHZ31202 AHZ31203 AHZ31204 AHZ31205 AHZ31206 AHZ31207 AHZ31208 AHZ31209 AHZ31210 AHZ31211 AHZ31212 AHZ31213 AHZ31214 AHZ31215 AHZ31216 AHZ31217 AHZ31218 AHZ31219 AHZ31220 AHZ31222 AHZ31223 AHZ31224 AHZ31225 AHZ31226 AHZ31228 AHZ31229 AHZ31230 AHZ31231 AHZ31232 AHZ31233 AHZ31234 AHZ31238 AHZ31239 AHZ31240 AHZ31241 AHZ31242 AHZ31245 AHZ31246 AHZ31248 AHZ31249 AHZ31251 AHZ31253 AIB55783 AIB55784 AIG13067 AIP90389 AIV43945 AIV43946 AIW80229 AIW80232 AIW80233 AIW80235 AIW80238 AIW80239 AIZ97522 AJA90824 AJA90825 AKE47359 BAA08086 BAA08628 BAA09469 BAA10906 BAA13099 BAA13587 BAA20564 BAA22609 BAA22610 BAA22611 BAA24408 BAA28762 BAB03347 BAB16681 BAC02937 BAC02938 BAC02939 BAC66086 BAC66087 BAD15071 BAD80735 BAE78959 BAG32232 BAG32233 BAG32234 BAG32283 BAG32284 BAG32285 BAG32287 BAG84657 BAH23562 BAH83700 BAH84972 BAH84973 BAH84974 BAH85280 BAH85282 BAH85284 BAI78056 BAJ46502 BAJ46503 BAJ46506 BAJ46507 BAJ46508 BAL04864 BAL04865 BAL04867 BAM64865 BAM64866 BAM64867 BAM64868 BAM64871 BAM64872 BAM64873 BAM64874 BAM64875 BAM67055 BAM67056 BAM84177 BAM84178 BAM84179 BAM84180 BAM84181 BAM84184 BAM84185 BAM84186 BAM84187 BAN59783 BAN59789 BAN59795 BAN59801 BAN59807 BAN59813 BAN59825 BAN59831 BAN59837 BAN59843 BAO01158 BAO73159 BAO73160 BAO73161 BAO73163 BAO73164 CAA04626 CAA04627 CAA04628 CAA08810 CAA09450 CAA10009 CAA27687 CAA34642 CAA36690 CAA45844 CAA45845 CAA46165 CAA46532 CAA46533 CAA46534 CAA48333 CAA51510 CAA52390 CAA53193 CAA61270 CAA61272 CAA61324 CAA64675 CAA68151 CAA70858 CAA75604 CAA76721 CAA76722 CAA76723 CAA76897 CAA86217 CAB41972 CAB42824 CAB45249 CAB51036 CAB53345 CAB56284 CAB56638 CAB76922 CAB87811 CAB95662 CAC05373 CAC08181 CAC09420 CAC19086 CAC19360 CAC19573 CAC32843 CAC33572 CAC34577 CAC34578 CAC44767 CAD12395 CAD22866 CAD23046 CAD24479 CAD29646 CAD44948 CAD47818 CAD62436 CAD65908 CAD87537 CAD88257 CAD89003 CAD90053 CAD90054 CAD91390 CAD92860 CAE00446 CAE30289 CAE46444 CAE46451 CAH61416 CAI35917 CAI44592 CAI59633 CAI94542 CAJ00865 CAJ13641 CAJ33574 CAJ33575 CAJ33576 CAJ33577 CAJ33578 CAJ33579 CAJ33580 CAJ33582 CAJ33583 CAJ33584 CAJ33585 CAJ33586 CAJ33587 CAJ33588 CAJ33589 CAJ33590 CAJ33591 CAJ33592 CAJ33593 CAJ33594 CAJ33595 CAJ33596 CAJ33597 CAJ33598 CAJ33599 CAJ33600 CAJ33601 CAJ33602 CAJ33603 CAJ33604 CAJ33605 CAJ33606 CAJ33607 CAJ33608 CAJ33609 CAJ33610 CAJ33611 CAJ33612 CAJ33613 CAJ43560 CAJ80873 CAJ90451 CAK02791 CAK29680 CAL08016 CAL64826 CAL64830 CAL64833 CAL64834 CAL64835 CAL64836 CAL64839 CAL64843 CAL69438 CAL69440 CAL69441 CAL69442 CAL69444 CAL69445 CAL69969 CAL85404 CAL99241 CAM35456 CAM91694 CAN89494 CAO78755 CAO79098 CAO82436 CAP12035 CAP17406 CAP45391 CAP47342 CAP69806 CAQ16178 CAQ19355 CAQ51482 CAQ51483 CAQ51484 CAQ58205 CAQ58206 CAQ86516 CAQ86517 CAQ86518 CAR57938 CAR64525 CAT00929 CAT03465 CAT80030 CAV31551 CAX32515 CAX32516 CAX32517 CAX32518 CAX32519 CAX32520 CAX32521 CAX32522 CAX33897 CAX48958 CAX48959 CAX51966 CAX63105 CAX63757 CAX64424 CAX68268 CAY46412 CAY68338 CBE70285 CBE70345 CBH31054 CBI71214 CBL51939 CBL51940 CBL51941 CBL88501 CBL93954 CBM00857 CBM00858 CBM00859 CBM42726 CBM42729 CBW44084 CBW44086 CBW69641 CBX19716 CBX33209 CBZ05563 CBZ41221 CBZ46993 CCA30655 CCA61114 CCA63120 CCA63121 CCA63122 CCA63123 CCA63124 CCA63125 CCA63127 CCC15302 CCE34943 CCE67067 CCF23452 CCF76626 CCF77302 CCF77303 CCF77304 CCF77305 CCF77306 CCF77307 CCF77309 CCF77330 CCF77339 CCF77340 CCF77341 CCF77342 CCF77343 CCF77344 CCG80502 CCH63751 CCI39217 CCI51026 CCI61352 CCI61353 CCJ32594 CCL97784 CCL97790 CCM44103 CCM44104 CCM44105 CCM44106 CCM44107 CCM44108 CCM44109 CCM44110 CCN80306 CCO01525 CCW45772 CCW45775 CCW45777 CCW45783 CCW45784 CCW45785 CCW45786 CCW45787 CCW45790 CDF59531 CDF66330 CDF66337 CDF66339 CDF66361 CDH92857 CDI43896 CDI44543 CDL67653 CDL67654 CDL67778 CDM87251 CDN39812 CDN39817 CDO19444 CDO33925 CDO67991 CEE15324 CEF49958 CEF52513 CEF52514 CEF52516 CEF52519 CEF52521 CEH24709 EAX03633 P01911 P01912 P04229 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 AF010142 AAB81176 AF017440 AAB70554 AF017441 AAB70555 AF291675 AAK91825 AF436097 AAL30416 AJ297583 CAC08823 AJ297585 CAC08825 AJ297586 CAC08826 AJ297587 CAC08827 AJ697892 CAG27025 AJ697893 CAG27026 AK289463 BAF82152 AK291987 BAF84676 AY626551 AAV34808 AY770514 AAV28303 AY935719 AAX33315 AY961062 AAX63450 AY961063 AAX63451 AY961065 AAX63453 AY961066 AAX63454 AY961068 AAX63456 AY961072 AAX63460 AY961073 AAX63461 AY961076 AAX63464 AY961077 AAX63465 AY961078 AAX63466 BC007920 AAH07920 BC008403 AAH08403 BC018832 BC018834 BC018835 BC024269 AAH24269 BC031023 AAH31023 BC033827 AAH33827 BC108922 AAI08923 BM671866 D86415 BAA13086 DB246210 DQ002917 AAY21682 DQ090958 AAY96423 DQ140279 AAZ76539 HG974574 CDP32884 HG974596 CDP32906 HG974600 CDP32910 HM067861 ADI59573 HM067862 ADI59574 HM067863 ADI59575 HQ447401 ADQ31887 KJ534866 AHW56506 L02545 AAA59777 L42143 AAA67104 L76133 AAL40069 M11161 AAA59781 M11867 AAA36274 M14191 AAA36289 M14661 AAA59799 M14662 AAA59800 M15069 AAA59809 M15074 AAA59810 M16957 AAA36279 M16958 AAA36280 M16959 AAA36281 M17378 AAA59801 M17381 AAA59805 M17384 AAA36295 M20138 AAA59832 M20430 AAA59831 M20504 AAA59827 M21008 AAA59780 M25265 AAA57260 M25266 AAA57259 M26038 AAA59794 M27635 AAA81550 M28583 AAA59680 M28584 AAA59681 M30179 AAA59842 M33600 AAA59782 U09201 AAA17992 U37582 AAA79205 U56640 AAC02715 U65585 AAD43827 U95817 AAD00817 X00699 CAA25295 X00700 CAA25296 X02902 CAA26660 X03069 CAA26873 NM_001243965 NP_001230894 NM_002124 NP_002115 |
Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loa |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
Top Pathways | Leishmaniasis, Influenza A, HTLV-I infection, Tuberculosis, Herpes simplex infection |
Anti-HLA class II, DRB1-3 chain antibody (Biotin) - ab193638 from Abcam
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Anti-HLA class II, DRB1-3 chain antibody (HRP) - ab193646 from Abcam
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Anti-HLA Class II DR13 antibody [4i134] - ab31257 from Abcam
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Anti-HLA Class II DR4 antibody - ab98106 from Abcam
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Anti-HLA Class II DR4 antibody [8.L.335] - ab33903 from Abcam
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Anti-HLA Class II DR7 antibody [4i127] - ab34054 from Abcam
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Anti-HLA Class II DRB1 antibody - ab98108 from Abcam
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Anti-HLA Class II DRB1 antibody - ab202343 from Abcam
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Anti-HLA Class II DRB1 antibody - ab168534 from Abcam
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Anti-HLA Class II DRB1 antibody [EPR6148] - ab133578 from Abcam
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Anti-HLA Class II DRB1 antibody [EPR6149] - ab124676 from Abcam
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Anti-HLA Class II DRB1 antibody (FITC) - ab193620 from Abcam
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Anti-HLA DR beta antibody [DA2] - ab20184 from Abcam
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Anti-HLA DR beta antibody [TAL 14.1] - ab20183 from Abcam
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Anti-HLA DR beta antibody [TDR 31.1] - ab20182 from Abcam
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Anti-HLA DR7+DR beta antibody [TAL 13.1] - ab20185 from Abcam
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Anti-HLA DRB1 antibody - ab153910 from Abcam
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Anti-HLA DRB1 antibody - ab92371 from Abcam
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Anti-HLA DRB1 antibody - ab89315 from Abcam
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Anti-HLA DRB1 antibody - ab191238 from Abcam
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Anti-HLA-DRB1 Antibody (aa122-154) - LS-C344421 from LifeSpan Bioscience
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Anti-HLA-DRB1 Antibody (aa103-137) - LS-C344219 from LifeSpan Bioscience
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Anti-HLA-DRB1 Antibody (aa30-58) - LS-C203667 from LifeSpan Bioscience
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Anti-HLA-DRB1 Antibody (N-Terminus, AP) - LS-C219721 from LifeSpan Bioscience
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Anti-HLA-DRB1 Antibody (N-Terminus, FITC) - LS-C219725 from LifeSpan Bioscience
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