PTCH1

Gene Symbol PTCH1
Entrez Gene 5727
Alt Symbol BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11
Species Human
Gene Type protein-coding
Description patched 1
Other Description PTCH protein +12b|PTCH protein +4'|PTCH protein -10|PTCH protein -3,4,5|protein patched homolog 1
Swissprots Q5VZC2 Q5R1U9 Q5R1U7 Q13463 A3KBI9 Q13635 E9PEJ8 Q86XG7 Q5VZC0 Q5R1V0
Accessions AAR21238 AAR21239 AAR21240 EAW92631 EAW92632 Q13635 AB189436 BAD74184 AB189437 BAD74185 AB189438 BAD74186 AB189439 BAD74187 AB189440 BAD74188 AB209495 BAD92732 AB212827 AB212828 BAF47711 AB214500 BAE45300 AB233422 BAE45302 AB233423 BAE45303 AB233424 BAE45304 AB239329 BAF47712 AI358880 AI494442 AK124593 BAC85893 AK130256 BC043542 AAH43542 BC152919 AAI52920 BF195352 BM974119 BX117041 CR744004 DB093644 U43148 AAC50496 U59464 AAC50550 XM_005252102 XP_005252159 XM_011518868 XP_011517170 XM_011518869 XP_011517171 XM_011518870 XP_011517172 XM_011518871 XP_011517173 XM_011518872 XP_011517174 XM_011518873 XP_011517175 XM_011518874 XP_011517176 NM_000264 NP_000255 NM_001083602 NP_001077071 NM_001083603 NP_001077072 NM_001083604 NP_001077073 NM_001083605 NP_001077074 NM_001083606 NP_001077075 NM_001083607 NP_001077076
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. {ECO:0000269|PubMed:21537345}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway, Proteoglycans in cancer

Human-PTCH1-cDNA-Clone - DC07531 from Abgent, a WuXi AppTec company

Prices $247.05
Sizes 10 µg
Species Human
Accession BC043542

Mouse Patched 1/PTCH (NP_032983) VersaClone cDNA - RDC1109 from R&D Systems

Prices $799.00
Sizes 10 µg
Species Mouse

Human Patched 1/PTCH (AAC50550) VersaClone cDNA - RDC1088 from R&D Systems

Prices $799.00
Sizes 10 µg
Species Human

PTCH1 - MBS1266566 from MyBioSource

Species Human
Accession BC043542

Human PTCH1 cDNA clone(NM_001083603.1) - CDFH015444 from Creative Biomart

Species Human
Accession NM_001083603.1

Human PTCH1 cDNA clone(NM_001083606.1) - CDFH015445 from Creative Biomart

Species Human
Accession NM_001083606.1

Human PTCH1 cDNA clone(NM_001083607.1) - CDFH015446 from Creative Biomart

Species Human
Accession NM_001083607.1

Human PTCH1 cDNA clone(NM_001083602.1) - CDFH015447 from Creative Biomart

Species Human
Accession NM_001083602.1

Human PTCH1 cDNA clone(NM_001083604.1) - CDFH015448 from Creative Biomart

Species Human
Accession NM_001083604.1

Human PTCH1 cDNA clone(NM_001083605.1) - CDFH015449 from Creative Biomart

Species Human
Accession NM_001083605.1

Human PTCH1 ORF Clone(NM_001083602.1) - CDCR346095 from Creative Biomart

Species Human
Accession NM_001083602.1

Human PTCH1 ORF Clone(NM_001083602.1) - CDCR346096 from Creative Biomart

Species Human
Accession NM_001083602.1

Human PTCH1 ORF Clone(NM_001083603.1) - CDCR346097 from Creative Biomart

Species Human
Accession NM_001083603.1

Human PTCH1 ORF Clone(NM_001083603.1) - CDCR346098 from Creative Biomart

Species Human
Accession NM_001083603.1

Human PTCH1 ORF Clone(NM_001083604.1) - CDCR346099 from Creative Biomart

Species Human
Accession NM_001083604.1

Human PTCH1 ORF Clone(NM_001083604.1) - CDCR346100 from Creative Biomart

Species Human
Accession NM_001083604.1

Human PTCH1 ORF Clone(NM_001083605.1) - CDCR346101 from Creative Biomart

Species Human
Accession NM_001083605.1

Human PTCH1 ORF Clone(NM_001083605.1) - CDCR346102 from Creative Biomart

Species Human
Accession NM_001083605.1

Human PTCH1 ORF Clone(NM_001083606.1) - CDCR346103 from Creative Biomart

Species Human
Accession NM_001083606.1

Human PTCH1 ORF Clone(NM_001083606.1) - CDCR346104 from Creative Biomart

Species Human
Accession NM_001083606.1

Human PTCH1 ORF Clone(NM_001083607.1) - CDCR346105 from Creative Biomart

Species Human
Accession NM_001083607.1

Human PTCH1 ORF Clone(NM_001083607.1) - CDCR346106 from Creative Biomart

Species Human
Accession NM_001083607.1

Human PTCH1 ORF Clone(NM_001083604.1) - CDCR346099 from Creative biogene

Species Human

Human PTCH1 ORF Clone(NM_001083606.1) - CDCR346103 from Creative biogene

Species Human
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