PTCH1

Gene Symbol PTCH1
Entrez Gene 5727
Alt Symbol BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11
Species Human
Gene Type protein-coding
Description patched 1
Other Description PTCH protein +12b|PTCH protein +4'|PTCH protein -10|PTCH protein -3,4,5|protein patched homolog 1
Swissprots Q5VZC2 Q5R1U9 Q5R1U7 Q13463 A3KBI9 Q13635 E9PEJ8 Q86XG7 Q5VZC0 Q5R1V0
Accessions AAR21238 AAR21239 AAR21240 EAW92631 EAW92632 Q13635 AB189436 BAD74184 AB189437 BAD74185 AB189438 BAD74186 AB189439 BAD74187 AB189440 BAD74188 AB209495 BAD92732 AB212827 AB212828 BAF47711 AB214500 BAE45300 AB233422 BAE45302 AB233423 BAE45303 AB233424 BAE45304 AB239329 BAF47712 AI358880 AI494442 AK124593 BAC85893 AK130256 BC043542 AAH43542 BC152919 AAI52920 BF195352 BM974119 BX117041 CR744004 DB093644 U43148 AAC50496 U59464 AAC50550 XM_005252102 XP_005252159 XM_011518868 XP_011517170 XM_011518869 XP_011517171 XM_011518870 XP_011517172 XM_011518871 XP_011517173 XM_011518872 XP_011517174 XM_011518873 XP_011517175 XM_011518874 XP_011517176 NM_000264 NP_000255 NM_001083602 NP_001077071 NM_001083603 NP_001077072 NM_001083604 NP_001077073 NM_001083605 NP_001077074 NM_001083606 NP_001077075 NM_001083607 NP_001077076
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. {ECO:0000269|PubMed:21537345}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway, Proteoglycans in cancer

PTCH1 (C53A3) Rabbit mAb - 2468 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C53A3
Western blot analysis of total cell lysates from COS cells, untransfected or transiently transfected with a human PTCH1 expression construct, using PTCH1 (C53A3) Rabbit mAb.

patched (C-20) - sc-6147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
patched (C-20): sc-6147. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing membrane and cytoplasmic staining of cells in red pup.

patched (G-19) - sc-6149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
patched (G-19): sc-6149. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tissue showing membrane and cytoplasmic staining.

patched (H-267) - sc-9016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
patched (H-267): sc-9016. Western blot analysis of patched expression in HeLa whole cell lysate (A), mouse testis (B) and mouse embryo (C) tissue extracts.

patched (L-20) - sc-34122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Patched / PTCH1 antibody - ab53715 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Patched / PTCH1 antibody (ab53715) at 1/500 dilutionLane 1 : Extracts from mouse muscle cells, minus immunising peptideLane 2 : Extracts from mouse muscle cells, plus immunising peptide

Anti-Patched / PTCH1 antibody - ab51983 from Abcam

Prices $382.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Patched / PTCH1 antibody (ab51983) at 1 µg/ml + Human Brain lysate in RIPA buffer at 35 µg

Anti-Patched / PTCH1 antibody - ab129341 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab129341 at 5 µg/ml staining Patched / PTCH1 in Formalin-Fixed, Paraffin-Embedded Human Small Intestine tissue by immunohistochemistry.

Anti-Patched / PTCH1 antibody - ab55629 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55629 Patched / PTCH antibody at 1ug/ml.

Anti-PTCH1 / Patched Antibody (aa1235-1251) - LS-C2995 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (Pro1307) - LS-C38104 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-PTCH1 / Patched Antibody (aa269-279) - LS-C40590 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (Internal) - LS-C54781 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody - LS-C87098 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (aa269-279) - LS-C93081 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (N-Terminus) - LS-C145062 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (aa260-277) - LS-C149021 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (aa936-354) - LS-C149020 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (Biotin) - LS-C180635 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (Internal) - LS-C55339 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of Human Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PTCH1 / Patched Antibody (DY650) - LS-C180636 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (DY488) - LS-C180637 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (DY550) - LS-C180639 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (C-Terminus) - LS-C209981 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-PTCH1 / Patched Antibody (N-Terminus) - LS-C209982 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
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