| Gene Symbol |
ABCC6
|
| Entrez Gene |
368
|
| Alt Symbol |
ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
|
| Other Description |
ATP-binding cassette sub-family C member 6|anthracycline resistance-associated protein|multi-specific organic anion transporter E|multidrug resistance-associated protein 6
|
| Swissprots |
A8Y988 A2RRN8 P78420 A8KIG6 E7ESW8 Q8TCY8 O95255 Q9UMZ7
|
| Accessions |
AAC15785 EAW53950 EAW53951 EAW53952 O95255 AF076622 AAC79696 AF168791 AAD51293 AI074459 AK298295 BAG60553 AM711638 CAN84639 AM774324 CAO81806 AY078405 AAL83711 BC050733 AAH50733 BC131732 AAI31733 DC361874 XM_011522479 XP_011520781 XM_011522480 XP_011520782 XM_011522481 XP_011520783 XM_011522482 XP_011520784 XM_011546696 XP_011544998 XM_011546697 XP_011544999 XR_932836 XR_932837 XR_932838 XR_951901 XR_951902 XR_951903 NM_001079528 NP_001072996 NM_001171 NP_001162
|
| Function |
Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). {ECO:0000269|PubMed:11880368}.
|
| Subcellular Location |
Isoform 1: Basolateral cell membrane {ECO:0000269|PubMed:12901863, ECO:0000269|PubMed:23625951}; Multi- pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12901863, ECO:0000269|PubMed:23625951}.
|
| Tissue Specificity |
Expressed in kidney and liver. Very low expression in other tissues.
|
| Top Pathways |
ABC transporters
|
![Western Blot: MRP6 Overexpression Lysate (Denatured) [H00000368-T01] - ABCC6 transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/28926_MRP6-Overexpression-Lysate-(Denatured)-Western-Blot-H00000368-T01-img0005.jpg)