| Gene Symbol | SGPL1 |
|---|---|
| Entrez Gene | 8879 |
| Alt Symbol | S1PL, SPL |
| Species | Human |
| Gene Type | protein-coding |
| Description | sphingosine-1-phosphate lyase 1 |
| Other Description | SP-lyase 1|SPL 1|hSPL|sphingosine-1-phosphate aldolase |
| Swissprots | Q7Z732 Q9ULG8 O95470 B2RBD4 Q9UN89 |
| Accessions | CAM35395 EAW54414 O95470 AB033078 BAA86566 AF144638 AAD44755 AJ011304 CAA09590 AK023873 AK308610 AK314615 BAG37181 BC031338 BC041567 BC051238 BC052991 AAH52991 BC068061 BP314104 XM_005270263 XP_005270320 XM_006718053 XP_006718116 XM_011540316 XP_011538618 XM_011540317 XP_011538619 XM_011540318 XP_011538620 XM_011540319 XP_011538621 NM_003901 NP_003892 |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein. |
| Tissue Specificity | Found in liver and kidney. {ECO:0000269|PubMed:11018465}. |
| Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |