Gene Symbol | LIAS |
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Entrez Gene | 11019 |
Alt Symbol | HUSSY-01, LAS, LIP1, LS, PDHLD |
Species | Human |
Gene Type | protein-coding |
Description | lipoic acid synthetase |
Other Description | LS|lip-syn|lipoate synthase|lipoyl synthase, mitochondrial |
Swissprots | Q8IV62 C9JCF6 O43766 A8K873 |
Accessions | CBN72404 CBN72413 EAW92932 EAW92933 EAW92934 O43766 AI373464 AJ224162 CAA11859 AK026289 AK291985 BAF84674 AK292238 BAF84927 AK303429 BAG64479 AL528262 AV729111 BC023635 AAH23635 BC062751 AAH62751 BF434814 HQ447772 ADQ32257 XM_006713990 XP_006714053 NM_001278590 NP_001265519 NM_001278591 NP_001265520 NM_001278592 NP_001265521 NM_006859 NP_006850 NM_194451 NP_919433 |
Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}. |
Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123}. |
Top Pathways | Lipoic acid metabolism |
LIAS CRISPR/Cas9 KO Plasmid (h) - sc-409802 from Santa Cruz Biotechnology
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LIAS HDR Plasmid (h) - sc-409802-HDR from Santa Cruz Biotechnology
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LIAS Double Nickase Plasmid (h) - sc-409802-NIC from Santa Cruz Biotechnology
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LIAS Double Nickase Plasmid (h2) - sc-409802-NIC-2 from Santa Cruz Biotechnology
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LIAS CRISPR Activation Plasmid (h) - sc-409802-ACT from Santa Cruz Biotechnology
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LIAS CRISPR Activation Plasmid (h2) - sc-409802-ACT-2 from Santa Cruz Biotechnology
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LIAS Lentiviral Activation Particles (h) - sc-409802-LAC from Santa Cruz Biotechnology
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LIAS Lentiviral Activation Particles (h2) - sc-409802-LAC-2 from Santa Cruz Biotechnology
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LIAS siRNA (h) - sc-88901 from Santa Cruz Biotechnology
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LIAS shRNA Plasmid (h) - sc-88901-SH from Santa Cruz Biotechnology
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LIAS shRNA (h) Lentiviral Particles - sc-88901-V from Santa Cruz Biotechnology
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LIAS RNAi - H00011019-R02 from Novus Biologicals
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MISSION® esiRNA - EHU071591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11700 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11700 from Sigma-Aldrich
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LIAS siRNA (Human) - CRH7528 from Cohesion Biosciences
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LIAS RNAi - H00011019-R01 from Novus Biologicals
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shRNA set against Human LIAS (NM_006859.2) - SHH330191 from Creative biogene
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shRNA set against Human LIAS(NM_194451.1) - SHH148997 from Creative biogene
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shRNA set against Human LIAS(NM_006859.2) - SHH149015 from Creative biogene
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Human LIAS siRNA - orb268030 from Biorbyt
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LIAS shRNA Plasmid (Human) - CHH7528 from Cohesion Biosciences
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LIAS miRNA 3'UTR clone - MiUTR1H-05665 from Creative biogene
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LIAS miRNA 3'UTR clone - MiUTR1H-05666 from Creative biogene
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