| Gene Symbol |
LIAS
|
| Entrez Gene |
11019
|
| Alt Symbol |
HUSSY-01, LAS, LIP1, LS, PDHLD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lipoic acid synthetase
|
| Other Description |
LS|lip-syn|lipoate synthase|lipoyl synthase, mitochondrial
|
| Swissprots |
Q8IV62 C9JCF6 O43766 A8K873
|
| Accessions |
CBN72404 CBN72413 EAW92932 EAW92933 EAW92934 O43766 AI373464 AJ224162 CAA11859 AK026289 AK291985 BAF84674 AK292238 BAF84927 AK303429 BAG64479 AL528262 AV729111 BC023635 AAH23635 BC062751 AAH62751 BF434814 HQ447772 ADQ32257 XM_006713990 XP_006714053 NM_001278590 NP_001265519 NM_001278591 NP_001265520 NM_001278592 NP_001265521 NM_006859 NP_006850 NM_194451 NP_919433
|
| Function |
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}.
|
| Subcellular Location |
Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123}.
|
| Top Pathways |
Lipoic acid metabolism
|