MPDZ

Gene Symbol MPDZ
Entrez Gene 8777
Alt Symbol HYC2, MUPP1
Species Human
Gene Type protein-coding
Description multiple PDZ domain protein
Other Description multi-PDZ domain protein 1
Swissprots Q5JUC4 O75970 Q5VZ62 Q5CZ80 B2RTS3 B7ZMI4 O43798 Q8N790 Q5JUC3 Q5JTX7 A6NLC2 Q4LE30 Q5JTX6 Q5JTX3
Accessions EAW58704 EAW58705 EAW58706 O75970 AB210041 BAE06123 AF093419 AAC61870 AJ001319 CAA04680 AK058011 AK074721 BAG51991 AK091945 BAG52447 AK098775 BAC05409 AK294823 BAG57936 AK294976 BAG58047 AK307924 AK307988 AK316489 BAH14860 BC140793 AAI40794 BC144564 AAI44565 BC172387 AAI72387 BU621500 CR936648 CAI56786 CX782625 HG501896 XM_005251622 XP_005251679 XM_005251623 XP_005251680 XM_006716885 XP_006716948 XM_006716886 XP_006716949 XM_006716887 XP_006716950 XM_006716888 XP_006716951 XM_006716889 XP_006716952 XM_006716890 XP_006716953 XM_006716891 XP_006716954 NM_001261406 NP_001248335 NM_001261407 NP_001248336 NM_003829 NP_003820
Function Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. {ECO:0000250, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.
Subcellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. {ECO:0000250}.
Tissue Specificity Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9537516}.
Top Pathways Tight junction

MPDZ (E-12) - sc-135503 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MPDZ (N-13) - sc-135504 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Mupp1 antibody - ab77508 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab77508 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab77508, 1/200 dilution) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Mupp1 antibody - ab101276 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mupp1 antibody (ab101276) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-Mupp1 antibody - ab101277 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mupp1 antibody (ab101277) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-MPDZ / MUPP1 Antibody (aa775-825) - LS-C289588 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MPDZ / MUPP1 Antibody (aa1125-1150) - LS-C289589 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MPDZ / MUPP1 Antibody (aa1691-1740) IHC-plus™ - LS-B5738 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MPDZ antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5738 concentration 5 ug/ml.

MUPP1 Antibody - NBP1-54331 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUPP1 Antibody [NBP1-54331] - Hela, 293T cell lysate, Antibody Titration: 0.2-1 ug/ml

MUPP1 Antibody - NBP1-87839 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUPP1 Antibody [NBP1-87839] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

MUPP1 Antibody - NBP1-49975 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUPP1 Antibody [NBP1-49975] - Detection of Human MUPP1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-MUPP1 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. MUPP1 was also immunoprecipitated by rabbit anti-MUPP1 antibody which recognizes an upstream epitope. For blotting immunoprecipitated MUPP1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A and B).

MUPP1 Antibody - NBP1-49974 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MUPP1 Antibody [NBP1-49974] - Detection of Human MUPP1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-MUPP1 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. MUPP1 was also immunoprecipitated by rabbit anti-MUPP1 antibody which recognizes a downstream epitope. For blotting immunoprecipitated MUPP1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A and B).

MUPP1/MPDZ Polyclonal Antibody - bs-12099R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12099R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12099R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12099R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12099R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, Cy3 Conjugated - bs-12099R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, Cy5 Conjugated - bs-12099R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, Cy5.5 Conjugated - bs-12099R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, Cy7 Conjugated - bs-12099R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, FITC Conjugated - bs-12099R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, Biotin Conjugated - bs-12099R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MUPP1/MPDZ Polyclonal Antibody, HRP Conjugated - bs-12099R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MPDZ antibody produced in rabbit - HPA026686 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MPDZ: <B>Cat. No. HPA026686</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic and membranous positivity in exocrine cells.
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