CD74

Gene Symbol CD74
Entrez Gene 972
Alt Symbol DHLAG, HLADG, II, Ia-GAMMA
Species Human
Gene Type protein-coding
Description CD74 molecule, major histocompatibility complex, class II invariant chain
Other Description CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)|HLA class II histocompatibility antigen gamma chain|HLA-DR antigens-associated invariant chain|HLA-DR-gamma|Ia-associated invariant chain|MHC HLA-DR gamma chain|gamma chain of class II antigens|p33
Swissprots D3DQG3 A8K7R1 Q8SNA0 B4DNE8 Q8WLP6 Q5U0J8 D3DQG4 Q14597 Q29832 P04233
Accessions AAA36033 CAA27046 CAA27047 EAW61727 EAW61728 EAW61729 EAW61730 EAW61731 P04233 AK292076 BAF84765 AK297889 BAG60210 AK300669 BAG62354 AK308929 BC018726 AAH18726 BC024272 AAH24272 BF796148 BT019505 AAV38312 DC354760 DQ892005 ABM82931 DQ895194 ABM86120 K01144 AAA36304 M28588 AAA58655 M28589 AAO49820 M28590 AAA35996 X00497 CAA25192 NM_001025158 NP_001020329 NM_001025159 NP_001020330 NM_004355 NP_004346
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Subcellular Location Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Top Pathways Tuberculosis, Herpes simplex infection, Antigen processing and presentation

CD74 (A-6) - sc-166047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (A-6): sc-166047. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

CD74 (By2) - sc-20062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (By2): sc-20062. Western blot analysis of CD74 expression in NAMALWA whole cell lysate.

CD74 (C-16) - sc-5438 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD74 (C-16): sc-5438. Western blot analysis of CD74 expression in BJAB (A) and NAMALWA (B) whole cell lysates.

CD74 (D-6) - sc-137217 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (D-6): sc-137217. Western blot analysis of CD74 expression in BJAB whole cell lysate.

CD74 (M-B741) - sc-65272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (M-B741): sc-65272. Western blot analysis of CD74 expression in NAMALWA (A), BJAB (B) and IB4 (C) whole cell lysates.

CD74 (LN-2) - sc-6262 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (LN-2): sc-6262. Western blot analysis of CD74 expression in BJAB whole cell lysate.

CD74 (FL-296) - sc-20082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD74 (FL-296): sc-20082. Western blot analysis of CD74 expression in NAMALWA whole cell lysate.

CD74 (PIN.1) - sc-47742 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (PIN.1): sc-47742. Western blot analysis of CD74 expression in BJAB (A), NAMALWA (B) and IB4 (C) whole cell lysates.

CD74 (2X31) - sc-70781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD74 (2X31): sc-70781. Western blot analysis of CD74 expression in NAMALWA (A), IB4 (B), J774.A1 (C) and BJAB (D) whole cell lysates.

CD74L (K-18) - sc-5441 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD74L (K-18): sc-5441. Western blot analysis of CD74L expression in non-transfected: sc-110760 (A) and mouse CD74 transfected: sc-110744 (B) 293 whole cell lysates.

CD74L (F-17) - sc-5440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD74L (F-17): sc-5440. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in white pulp and cells in red pulp.

Anti-CD74 antibody - ab64772 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CD74 was immunoprecipitated using 0.5mg Raji whole cell extract, 5µg of Rabbit polyclonal to CD74 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, Raji whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab64772.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 34kDa; CD74

Anti-CD74 antibody - ab202844 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling CD74 with ab202844 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-CD74 antibody - ab97479 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CD74 antibody (ab97479) at 1/5000 dilution + Raji whole cell lysate at 30 µg

Anti-CD74 antibody - ab155784 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD74 antibody (ab155784) at 1/1000 dilutionLane 1 : Raji whole cell lysate Lane 2 : K652 whole cell lysate Lysates/proteins at 30 µg per lane.

Anti-CD74 antibody [2D1B3] - N-terminal - ab181465 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D1B3
+ Raji cell line lysate with Anti-CD74 antibody [2D1B3] - N-terminal (ab181465) at 1/500 dilution

Anti-CD74 antibody [Bu45] - ab54428 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Bu45

Anti-CD74 antibody [Bu45] (FITC) - ab54213 from Abcam

Prices $437.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Bu45

Anti-CD74 antibody [CerCLIP.1] - ab22606 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CerCLIP.1

Anti-CD74 antibody [EPR4064] - ab108393 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4064
Anti-CD74 antibody [EPR4064] (ab108393) at 1/1000 dilution + Ramos cell lysate at 10 µg

Anti-CD74 antibody [EPR4065] (HRP) - ab197715 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR4065
Anti-CD74 antibody [EPR4065] (HRP) (ab197715) at 1/5000 dilution + Tonsil (Human) Whole Cell Lysate - adult normal tissue (ab29615) at 10 µgdeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD74 antibody [LN2] - ab9514 from Abcam

Prices $390.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone LN2
ab9514 staining human tonsil by IHC-P.

Anti-CD74 antibody [LN2] (Biotin) - ab82597 from Abcam

Prices $372.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone LN2

Anti-CD74 antibody [LN2] (FITC) - ab82432 from Abcam

Prices $189.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone LN2
Overlay histogram showing RAMOS cells stained with ab82432 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab82432, 2µg/1x106 cells) for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 FITC (2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-CD74 antibody [LN2] (FITC) - ab190106 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone LN2
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