TRAF3

Gene Symbol TRAF3
Entrez Gene 7187
Alt Symbol CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
Species Human
Gene Type protein-coding
Description TNF receptor-associated factor 3
Other Description CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1-associated protein 1
Swissprots Q9UNL1 Q13076 Q13114 Q12990 B7Z8C4 Q13947 Q6AZX1
Accessions EAW81795 EAW81796 EAW81797 Q13114 AF110908 AAD29276 AK303172 BAH13910 BC075086 AAH75086 BC075087 AAH75087 BQ000015 BX247977 CAD62311 L38509 AAA68195 U15637 AAA56753 U19260 AAA65732 U21092 AAC50112 XM_011537116 XP_011535418 XM_011537117 XP_011535419 XM_011537118 XP_011535420 XR_943512 NM_001199427 NP_001186356 NM_003300 NP_003291 NM_145725 NP_663777 NM_145726 NP_663778
Function Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubM
Subcellular Location Cytoplasm {ECO:0000305}. Endosome {ECO:0000250}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.
Top Pathways Hepatitis C, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Herpes simplex infection, Viral carcinogenesis

TRAF3 Antibody - 4729 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7 cells, untransfected (-) or transfected with human TRAF3 construct (+) using TRAF3 Antibody.

TRAF3 (C-20) - sc-949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF3 (C-20) PE: sc-949 PE. Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and TRAF3 transfected (solid orange histogram) IB4 cells. Dotted pink histogram represents the isotype control, normal rabbit IgG: sc-3871.

TRAF3 (G-6) - sc-6933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRAF3 (G-6): sc-6933. Immunofluorescence staining of methanol-fixed TRAF3-transfected COS cells showing cytoplasmic localization.

TRAF3 (H-122) - sc-1828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF3 (H-122): sc-1828. Western blot analysis of TRAF3 expression in TRAF3 transfected IB4 cells.

TRAF3 (H-20) - sc-948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF3 (H-20)-G: sc-948-G. Western blot analysis of TRAF3 expression in control (A) and TRAF3 transfected (B) whole cell lysates.

TRAF3 (M-51) - sc-1574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRAF3 (M-51): sc-1574. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse brain showing cytoplasmic localization.

Anti-TRAF3 antibody - ab36988 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TRAF3 antibody (ab36988) at 2 µg/mlLane 2 : Anti-TRAF3 antibody (ab36988) at 4 µg/mlLane 1 : Hela cell lysate.Lane 2 : Hela cell lysate.

Anti-TRAF3 antibody - ab62552 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TRAF3 antibody (ab62552) at 1 µg/mlLane 2 : Anti-TRAF3 antibody (ab62552) at 2 µg/mlLane 1 : 3T3 cell lysateLane 2 : 3T3 cell lysateLysates/proteins at 15 µg per lane.

Anti-TRAF3 antibody - ab155298 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TRAF3 antibody (ab155298) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-TRAF3 antibody - ab110781 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRAF3 antibody (ab110781) at 1 µg/mlLane 1 : Kidney (Human) Tissue Lysate - fetal normal tissueLane 2 : Fetal Liver (Human) Normal Tissue LysateLane 3 : Lung (Human) Whole Cell Lysate - fetal normal tissueLane 4 : Thymus (Human) Tissue Lysate - adult normal tissueLane 5 : Spleen (Human) Tissue Lysate - adult normal tissueLane 6 : Lymph node (Human) Tissue Lysate - adult normal tissueLane 7 : Bone Marrow (Human) Tissue Lysate - adult normal tissueLane 8 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TRAF3 antibody - ab172240 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TRAF3 antibody (ab172240) at 1 µg/mlLane 1 : TRAF3-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H+L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-TRAF3 antibody - ab58368 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58368 TRAF3 antibody at 1ug/ml.

Anti-TRAF3 antibody - ab13721 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of TRAF3 using ab13721 at 1:1000 dilution against 15 µg of (A) HeLa or (B) NIH3T3 cell lysate.

Anti-TRAF3 antibody [EP1730Y] - ab76147 from Abcam

Prices $99.00, $387.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1730Y
ab76147 staining TRAF3 in Malme-3 cells. The cells were fixed with 4% formaldehyde (10min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab76147 at 1/2000 dilution and ab195884, Rat monoclonal to Tubulin (Alexa Fluor® A647) at 1µg/ml. This was followed by an incubation at room temperature for 1h with ab150081, Goat polyclonal Secondary Antibody to Rabbit IgG (Alexa Fluor® A488) , at 1µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-TRAF3 antibody [EP1730Y] (Alexa Fluor® 647) - ab199823 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1730Y
ab199823 staining TRAF3 in A375 cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab199823 at 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 2µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in A375 cells fixed with 4% formaldehyde (10 min).

Anti-TRAF3 antibody [EPR1731] - ab110715 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR1731
All lanes : Anti-TRAF3 antibody [EPR1731] (ab110715) at 1/1000 dilutionLane 1 : MOLT4 cell lysateLane 2 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-TRAF3 Antibody (aa5-25) - LS-C10902 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody (C-Terminus) - LS-C10903 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody (N-Terminus) - LS-C10904 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody - LS-C90667 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-TRAF3 Antibody - LS-C48522 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody (aa550-600) - LS-C92940 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody (aa619-669) - LS-C92941 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody - LS-C148299 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TRAF3 Antibody (clone 1C5) - LS-C198367 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C5
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