Gene Symbol | RNASE2 |
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Entrez Gene | 6036 |
Alt Symbol | EDN, RAF3, RNS2 |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) |
Other Description | RNase 2|RNase UpI-2|eosinophil-derived neurotoxin|non-secretory ribonuclease|ribonuclease 2|ribonuclease A F3|ribonuclease US |
Swissprots | Q9H2B7 P10153 Q52M39 Q9UCG7 |
Accessions | AAG31577 AAG31578 AAG31579 AAG31580 AAG31581 AAG31582 AAG31583 AAG31584 AAG31585 CAA34546 CAA39459 CAC27640 CDG31919 EAW66435 P10153 BC093678 AAH93678 BC093680 AAH93680 BC096059 AAH96059 M24157 AAA52337 M28129 AAA50284 M30510 AAC82505 X55988 CAA39460 NM_002934 NP_002925 |
Function | This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:3458170}. |
Subcellular Location | Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule. |
Tissue Specificity | Liver, lung, spleen, leukocytes and body fluids. |
RNase 2 CRISPR/Cas9 KO Plasmid (h) - sc-408767 from Santa Cruz Biotechnology
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RNase 2 HDR Plasmid (h) - sc-408767-HDR from Santa Cruz Biotechnology
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RNase 2 Double Nickase Plasmid (h) - sc-408767-NIC from Santa Cruz Biotechnology
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RNase 2 Double Nickase Plasmid (h2) - sc-408767-NIC-2 from Santa Cruz Biotechnology
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RNase 2 CRISPR Activation Plasmid (h) - sc-408767-ACT from Santa Cruz Biotechnology
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RNase 2 CRISPR Activation Plasmid (h2) - sc-408767-ACT-2 from Santa Cruz Biotechnology
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RNase 2 Lentiviral Activation Particles (h) - sc-408767-LAC from Santa Cruz Biotechnology
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RNase 2 Lentiviral Activation Particles (h2) - sc-408767-LAC-2 from Santa Cruz Biotechnology
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RNase 2 siRNA (h) - sc-92235 from Santa Cruz Biotechnology
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RNase 2 shRNA Plasmid (h) - sc-92235-SH from Santa Cruz Biotechnology
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RNase 2 shRNA (h) Lentiviral Particles - sc-92235-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18345 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18345 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01179 from Sigma-Aldrich
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RNASE2 siRNA (Human) - CRH4087 from Cohesion Biosciences
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Eosinophil derived neurotoxin RNAi - H00006036-R01 from Novus Biologicals
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RNASE2 - MBS8205669 from MyBioSource
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shRNA set against Human RNASE2 (NM_002934.2) - SHH396304 from Creative biogene
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Human RNASE2 siRNA - orb264589 from Biorbyt
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RNASE2 shRNA Plasmid (Human) - CHH4087 from Cohesion Biosciences
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RNASE2 miRNA 3'UTR clone - MiUTR1H-08854 from Creative biogene
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