MRE11A

Gene Symbol	MRE11A
Entrez Gene	4361
Alt Symbol	ATLD, HNGS1, MRE11, MRE11B
Species	Human
Gene Type	protein-coding
Description	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Other Description	AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A
Swissprots	O43475 B3KTC7 P49959
Accessions	AAK18790 AAS79320 CCQ43331 EAW66930 EAW66931 EAW66932 EAW66933 EAW66934 P49959 AF022778 AAD10197 AF073362 AAC36249 AK095388 BAG53039 AK308318 BC005241 AAH05241 BC017823 AAH17823 BC063458 AAH63458 BF574168 BT006730 AAP35376 JF432288 ADZ15505 U37359 AAC78721 XM_005274008 XP_005274065 XM_006718842 XP_006718905 XM_011542837 XP_011541139 XR_947828 NM_005590 NP_005581 NM_005591 NP_005582
Function	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Subcellular Location	Nucleus {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Top Pathways	Homologous recombination, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Mre11 (phospho S678) peptide - ab112241 from Abcam Category Peptide

Human Mre11 (phospho S688) peptide - ab95863 from Abcam Category Peptide

Human Mre11 full length protein - ab114277 from Abcam Category Protein Source Wheat germ Species Human

Human Mre11 peptide - ab33124 from Abcam Category Peptide

Human Mre11 peptide - ab116269 from Abcam Category Peptide

Human Mre11 peptide - ab116270 from Abcam Category Peptide

MRE11A / MRE11 Antibody Blocking Peptide - LS-E20594 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MRE11A / MRE11 Antibody Blocking Peptide - LS-E20595 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MRE11A / MRE11 Antibody Blocking Peptide - LS-E30836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Mre11 Protein - H00004361-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MRE11A peptide - orb217629 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

MRE11A Blocking Peptide - 33R-2193 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MRE11A Blocking Peptide - 33R-7907 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MRE11 Blocking Peptide - abx062960 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Dog, Monkey

MRE11 - H00004361-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MRE11 - H00004361-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MRE11 Control Peptide - AP30566CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Meiotic Recombination 11 Homolog A (MRE11A), Human - 20-9419 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Human

MRE11 Peptide - 5547P from ProSci Category Peptide Species Human

MRE11A fusion protein - Ag1105 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MRE11A - MRE11A-28636TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Meiotic Recombination 11 Homolog A (MRE11A) - RPK113Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

MRE11 Blocking Peptide - CBP1766 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Dog, Monkey

MRE11 (L260) Peptide - BS1852P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

MRE11 (Q459) Peptide - BS2235P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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