MRE11A

Gene Symbol MRE11A
Entrez Gene 4361
Alt Symbol ATLD, HNGS1, MRE11, MRE11B
Species Human
Gene Type protein-coding
Description MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Other Description AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A
Swissprots O43475 B3KTC7 P49959
Accessions AAK18790 AAS79320 CCQ43331 EAW66930 EAW66931 EAW66932 EAW66933 EAW66934 P49959 AF022778 AAD10197 AF073362 AAC36249 AK095388 BAG53039 AK308318 BC005241 AAH05241 BC017823 AAH17823 BC063458 AAH63458 BF574168 BT006730 AAP35376 JF432288 ADZ15505 U37359 AAC78721 XM_005274008 XP_005274065 XM_006718842 XP_006718905 XM_011542837 XP_011541139 XR_947828 NM_005590 NP_005581 NM_005591 NP_005582
Function Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Subcellular Location Nucleus {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Top Pathways Homologous recombination, Non-homologous end-joining

Mre11 Antibody - 4895 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat (human), L929 (mouse), Neuro-2a (mouse) and C6 (rat) cells, using Mre11 Antibody.

Mre11 (31H4) Rabbit mAb - 4847 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 31H4
Western blot analysis of extracts from HeLa and K562 cells, using Mre11 Rabbit (31H4) mAb.

Phospho-Mre11 (Ser676) Antibody - 4859 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and HT-1080 cells, untreated or treated with UV, using Phospho-Mre11 (Ser676) Antibody (upper) or total Mre11 Antibody #4895 (lower).

MRE11 (C-16) - sc-5859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MRE11 (C-16): sc-5859. Western blot analysis of MRE11 expression in K-562 (A), HeLa (B) and Jurkat (C) whole cell lysates.

MRE11 (H-300) - sc-22767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MRE11 (H-300): sc-22767. Western blot analysis of MRE11 expression in Jurkat whole cell lysate.

MRE11 (T-15) - sc-5858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MRE11 (18) - sc-135992 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
MRE11 (18): sc-135992. Western blot analysis of MRE11 expression in HeLa whole cell lysate.

Anti-Mre11 (phospho S264) antibody - ab74148 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 (phospho S264) antibody (ab74148) at 1/500 dilutionLane 1 : 3T3 extract (treated with forskolin at 40nM for 30mins)Lane 2 : 3T3 extract (treated with forskolin at 40nM for 30mins) with phosphopeptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Mre11 (phospho S678) antibody - ab77631 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 (phospho S678) antibody (ab77631) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate with Human Mre11 (phospho S678) peptide (ab112241) at 1 µg/mlLane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate with Human Mre11 peptide (ab116269) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Mre11 antibody - ab33125 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 antibody (ab33125) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryIR Dye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-Mre11 antibody - ab168817 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach linitis plastica tissue labelling Mre11 with ab168817 at 1/1000 (1µg/ml). Detection: DAB.

Anti-Mre11 antibody - ab3621 from Abcam

Prices $379.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling Mre11 with ab3621 at 1/1000 (1µg/ml). Detection: DAB.

Anti-Mre11 antibody - ab30725 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 antibody (ab30725) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryIR Dye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-Mre11 antibody - ab154480 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Mre11 antibody (ab154480) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-Mre11 antibody - ab65131 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 antibody (ab65131) at 1/500 dilutionLane 1 : Extracts from RAW264.7 cellsLane 2 : Extracts from HT-29 cellsLane 3 : Extracts from LOVO cellsLane 4 : Extracts from LOVO cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Mre11 antibody - ab84495 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84495, at a dilution of 1/250, staining Mre11 in formalin fixed, paraffin embedded human basal cell carcinoma by Immunohistochemistry. Detection: DAB staining

Anti-Mre11 antibody - ab34754 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 antibody (ab34754) at 1/1000 dilutionLane 1 : 0.5 µg purified mouse Mre11 proteinLane 2 : 0.3 µg purified mouse Mre11 proteinLane 3 : 0.1 µg purified mouse Mre11 proteinLane 4 : 0.05 µg purified mouse Mre11 proteinSecondaryIRDye™800 conjugated Goat anti-Rabbit IgG [H&L] MX (611- 132-122) at 1/10000 dilution

Anti-Mre11 antibody - ab63368 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mre11 antibody (ab63368) at 1/500 dilutionLane 1 : Jurkat cell extracts treated with UV (15mins)Lane 2 : Jurkat cell extracts treated with UV (15mins) with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Mre11 antibody [12D7] - ab214 from Abcam

Prices $404.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12D7
ab214 staining Mre11 in human normal and gastric cancer tissue sections (20µm) by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with paraformaldehyde for 3 hours, permeabilized with 0.1% Triton X-100 and blocked with 5% serum for 1 hour at 23°C. Samples were incubated with primary antibody (1/200 in 3% BSA + 0.1% Triton X-100 in TBS buffer) for 12 hours at 4°C. An undiluted HRP-conjugated goat anti-mouse IgG polyclonal was used as the secondary antibody.See Abreview

Anti-Mre11 antibody [44B12] - ab119704 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 44B12
All lanes : Anti-Mre11 antibody [44B12] (ab119704) at 1/2000 dilutionLane 1 : HeLa cell lysateLane 2 : SK-N-MC cell lysateLane 3 : K562 cell lysateLane 4 : A431 cell lysateLane 5 : HepG2 cell lysateLane 6 : SK-BR3 cell lysateLane 7 : Ramos cell lysate

Anti-Mre11 antibody [EPR3471] - ab109623 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3471
All lanes : Anti-Mre11 antibody [EPR3471] (ab109623) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HT-29 cell lysateLane 3 : Jurkat cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-MRE11A / MRE11 Antibody (Leu260) - LS-C176685 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of MRE11 (L260) pAb in paraffin-embedded human lung carcinoma tissue.

Anti-MRE11A / MRE11 Antibody (aa182-582, clone 12D7) IHC-plus™ - LS-B1700 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 12D7
Anti-MRE11A / MRE11 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1700 concentration 5 ug/ml.

Anti-MRE11A / MRE11 Antibody (clone 1D8-A6) - LS-C197702 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D8-A6
MRE11A monoclonal antibody (M01), clone 1D8-A6 Western Blot analysis of MRE11A expression in HL-60.

Anti-MRE11A / MRE11 Antibody (aa1-207, Azide-free) - LS-C327941 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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