SLC4A4

Gene Symbol	SLC4A4
Entrez Gene	8671
Alt Symbol	HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC
Species	Human
Gene Type	protein-coding
Description	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Other Description	Na(+)/HCO3(-) cotransporter|electrogenic sodium bicarbonate cotransporter 1|kNBC1|sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)|solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type|solute carrier family 4, sodium bicarbonate cotransporter, member 5
Swissprots	Q9UIC0 Q9UIC1 Q9NRZ1 Q9H262 Q8NEJ2 O15153 Q9UP50 Q9Y6R1 C4B714
Accessions	EAX05639 EAX05640 EAX05641 EAX05642 EAX05643 EAX05644 Q9Y6R1 AA349118 AB470072 BAH58226 AF004813 AAD31379 AF007216 AAC51645 AF011390 AAC39840 AF053753 AAF21718 AF053754 AAF21719 AF069510 AAD42020 AF157492 AAF80343 AF310248 AAG47773 AK090968 AK226164 AK307594 AK308038 AV724814 AV726720 BC030977 AAH30977 BC127908 BE855478 CR749482 CAH18310 DA343084 DA378692 DA635432 EF531618 ABQ43327 XM_011532390 XP_011530692 NM_001098484 NP_001091954 NM_001134742 NP_001128214 NM_003759 NP_003750
Function	Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
Subcellular Location	Basolateral cell membrane {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077}; Multi- pass membrane protein {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250}.
Tissue Specificity	Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11743927, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14559244, ECO:0000269|PubMed:15329059, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
Top Pathways	Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC4A4 full length protein - ab132372 from Abcam Category Protein Source Wheat germ Species Human

Human SLC4A4 protein fragment - ab84337 from Abcam Category Protein Source E. coli Species Human

Human SLC4A4 protein fragment - ab119144 from Abcam Category Protein Source E. coli Species Human

SLC4A4 Recombinant Protein - H00008671-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SLC4A4 Partial Recombinant Protein - H00008671-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SLC4A4 Protein - NBC1-22950 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

SLC4A4 Protein (OPPA01846) - OPPA01846 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human SLC4A4 protein - orb81363 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

NBC1 protein (His tag) - 80R-1132 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

SLC4A4 / NBCE1 (Isoform 2) (1-424, His-tag) - AR09181PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SLC4A4 / NBCE1 (Isoform 2) (1-424, His-tag) - AR09181PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SLC4A4 / NBCE1 - H00008671-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLC4A4 / NBCE1 - H00008671-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SLC4A4 / NBCE1 - H00008671-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLC4A4 / NBCE1 - H00008671-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4, Human Recombinant - 228-11433-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human SLC4A4 - 228-11433-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human SLC4A4 - 228-11433-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

NBC1, 1-424aa, Human, His-tagged, Recombinant, E.coli - 01-2068 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

SLC4A4 fusion protein - Ag2490 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SLC4A4 Human - PRPS-695 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human SLC4A4 Protein - BP002273-PRO-688 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

NBC1, 1-424aa, Recombinant Protein - GWB-P1744B from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human SLC4A4 , His-tagged - SLC4A4-505H from Creative Biomart Category Protein Source E. Coli .

Recombinant Human SLC4A4, His-tagged - SLC4A4-31418TH from Creative Biomart Category Protein Source E. coli

Search more