SLC4A4

Gene Symbol SLC4A4
Entrez Gene 8671
Alt Symbol HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC
Species Human
Gene Type protein-coding
Description solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Other Description Na(+)/HCO3(-) cotransporter|electrogenic sodium bicarbonate cotransporter 1|kNBC1|sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)|solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type|solute carrier family 4, sodium bicarbonate cotransporter, member 5
Swissprots Q9UIC0 Q9UIC1 Q9NRZ1 Q9H262 Q8NEJ2 O15153 Q9UP50 Q9Y6R1 C4B714
Accessions EAX05639 EAX05640 EAX05641 EAX05642 EAX05643 EAX05644 Q9Y6R1 AA349118 AB470072 BAH58226 AF004813 AAD31379 AF007216 AAC51645 AF011390 AAC39840 AF053753 AAF21718 AF053754 AAF21719 AF069510 AAD42020 AF157492 AAF80343 AF310248 AAG47773 AK090968 AK226164 AK307594 AK308038 AV724814 AV726720 BC030977 AAH30977 BC127908 BE855478 CR749482 CAH18310 DA343084 DA378692 DA635432 EF531618 ABQ43327 XM_011532390 XP_011530692 NM_001098484 NP_001091954 NM_001134742 NP_001128214 NM_003759 NP_003750
Function Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
Subcellular Location Basolateral cell membrane {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077}; Multi- pass membrane protein {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250}.
Tissue Specificity Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11743927, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14559244, ECO:0000269|PubMed:15329059, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
Top Pathways Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), Human, ELISA Kit - E01E0394 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Electrogenic sodium bicarbonate cotransporter 1, ELISA Kit - MBS283012 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1, ELISA Kit - MBS282557 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7217672 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7236632 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7247406 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7234356 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7243066 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7235958 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7251069 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7247510 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7253662 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7218114 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS728007 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4), ELISA Kit - MBS7225305 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SLC4A4 ELISA Kit - E012900 from Biobool

Category ELISA Kit
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