| Gene Symbol | SLC4A4 |
|---|---|
| Entrez Gene | 8671 |
| Alt Symbol | HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
| Other Description | Na(+)/HCO3(-) cotransporter|electrogenic sodium bicarbonate cotransporter 1|kNBC1|sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)|solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type|solute carrier family 4, sodium bicarbonate cotransporter, member 5 |
| Swissprots | Q9UIC0 Q9UIC1 Q9NRZ1 Q9H262 Q8NEJ2 O15153 Q9UP50 Q9Y6R1 C4B714 |
| Accessions | EAX05639 EAX05640 EAX05641 EAX05642 EAX05643 EAX05644 Q9Y6R1 AA349118 AB470072 BAH58226 AF004813 AAD31379 AF007216 AAC51645 AF011390 AAC39840 AF053753 AAF21718 AF053754 AAF21719 AF069510 AAD42020 AF157492 AAF80343 AF310248 AAG47773 AK090968 AK226164 AK307594 AK308038 AV724814 AV726720 BC030977 AAH30977 BC127908 BE855478 CR749482 CAH18310 DA343084 DA378692 DA635432 EF531618 ABQ43327 XM_011532390 XP_011530692 NM_001098484 NP_001091954 NM_001134742 NP_001128214 NM_003759 NP_003750 |
| Function | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Subcellular Location | Basolateral cell membrane {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077}; Multi- pass membrane protein {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250}. |
| Tissue Specificity | Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11743927, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14559244, ECO:0000269|PubMed:15329059, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Top Pathways | Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion |