Gene Symbol | IGSF5 |
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Entrez Gene | 150084 |
Alt Symbol | GSF5, JAM4 |
Species | Human |
Gene Type | protein-coding |
Description | immunoglobulin superfamily, member 5 |
Other Description | JAM-4|immunoglobulin superfamily 5 like|immunoglobulin superfamily member 5|junctional adhesion molecule 4 |
Swissprots | Q9NSI5 |
Accessions | CAB90447 CCQ43066 Q9NSI5 AK092516 BAG52565 BC114922 BC156232 AAI56233 BC157006 AAI57007 HG511824 HG511825 HG511826 XM_011529472 XP_011527774 XM_011529473 XP_011527775 NM_001080444 NP_001073913 |
Function | Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. |
Top Pathways | Tight junction, Epithelial cell signaling in Helicobacter pylori infection |
IGSF5 / JAM4 Antibody Blocking Peptide - LS-E351 from LifeSpan Bioscience
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IGSF5-Antibody-N-term-Blocking-Peptide - BP10623a from Abgent, a WuXi AppTec company
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IGSF5 fusion protein - ag18224 from Proteintech Group
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IGSF5 fusion protein - Ag18169 from Proteintech Group
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Recombinant Human Immunoglobulin superfamily member 5(IGSF5) - CSB-YP889105HU CSB-EP889105HU CSB-BP889105HU CSB-MP889105HU from Cusabio
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JAM-4/IGSF5 Recombinant Protein Antigen - NBP2-34155PEP from Novus Biologicals
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IGSF5 Peptide, Human - M34GP07511H from Creative Peptides
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Immunoglobulin superfamily member 5 (IGSF5), Recombinant Protein - MBS1376082 from MyBioSource
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