| Gene Symbol |
IGSF5
|
| Entrez Gene |
150084
|
| Alt Symbol |
GSF5, JAM4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
immunoglobulin superfamily, member 5
|
| Other Description |
JAM-4|immunoglobulin superfamily 5 like|immunoglobulin superfamily member 5|junctional adhesion molecule 4
|
| Swissprots |
Q9NSI5
|
| Accessions |
CAB90447 CCQ43066 Q9NSI5 AK092516 BAG52565 BC114922 BC156232 AAI56233 BC157006 AAI57007 HG511824 HG511825 HG511826 XM_011529472 XP_011527774 XM_011529473 XP_011527775 NM_001080444 NP_001073913
|
| Function |
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
|
| Top Pathways |
Tight junction, Epithelial cell signaling in Helicobacter pylori infection
|