| Gene Symbol | IGSF5 |
|---|---|
| Entrez Gene | 150084 |
| Alt Symbol | GSF5, JAM4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | immunoglobulin superfamily, member 5 |
| Other Description | JAM-4|immunoglobulin superfamily 5 like|immunoglobulin superfamily member 5|junctional adhesion molecule 4 |
| Swissprots | Q9NSI5 |
| Accessions | CAB90447 CCQ43066 Q9NSI5 AK092516 BAG52565 BC114922 BC156232 AAI56233 BC157006 AAI57007 HG511824 HG511825 HG511826 XM_011529472 XP_011527774 XM_011529473 XP_011527775 NM_001080444 NP_001073913 |
| Function | Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. |
| Top Pathways | Tight junction, Epithelial cell signaling in Helicobacter pylori infection |