RASGRP2

Gene Symbol	RASGRP2
Entrez Gene	10235
Alt Symbol	CALDAG-GEFI, CDC25L
Species	Human
Gene Type	protein-coding
Description	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Other Description	F25B3.3 kinase-like protein|RAS guanyl nucleotide-releasing protein 2|RAS guanyl-releasing protein 2|calcium and DAG-regulated guanine nucleotide exchange factor I|calcium and diacylglycerol-regulated guanine nucleotide exchange factor I|cdc25-like protein|guanine exchange factor MCG7|hCDC25L
Swissprots	A6NDC7 Q9UL65 O00538 Q7LDG7
Accessions	CAI45372 EAW74281 EAW74282 EAW74283 Q7LDG7 AF043722 AAF07219 AF043723 AAF07220 AF081194 AAC79698 AK092852 AK092882 BAG52620 AK122694 BAG53672 AK124023 AK314637 BAG37199 BC110306 AAI10307 BC117151 AAI17152 DA286186 DB498812 HQ258466 ADR83220 U78170 AAD12741 Y12336 CAA73005 XM_005273707 XP_005273764 XM_011544718 XP_011543020 XM_011544719 XP_011543021 XM_011544720 XP_011543022 XM_011544721 XP_011543023 XM_011544722 XP_011543024 XM_011544723 XP_011543025 XM_011544724 XP_011543026 XM_011544725 XP_011543027 NM_001098670 NP_001092140 NM_001098671 NP_001092141 NM_153819 NP_722541 NM_005825
Function	Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846}.
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain where it is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:9341881, ECO:0000269|PubMed:9789079}.
Top Pathways	MAPK signaling pathway, Chemokine signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RasGRP2 (A-14) - sc-169112 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RasGRP2 (Y-13) - sc-169114 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RASGRP2 antibody - ab56658 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RASGRP2 antibody - N-terminal - ab170572 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RASGRP2 Antibody (clone 1E5) - LS-C139442 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E5

Anti-RASGRP2 Antibody - LS-C109417 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RASGRP2 Antibody (aa35-84) - LS-C112261 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RASGRP2 Antibody (aa7-34) - LS-C162459 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

RASGRP2 Antibody - NBP2-30038 from Novus Biologicals Prices $299.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

RASGRP2 Antibody - NBP1-86661 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RASGRP2 Antibody - NBP1-58871 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

RASGRP2 Antibody - NBP1-33315 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RASGRP2 Antibody (3D8) - H00010235-M09 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D8

RASGRP2 Antibody - NBP2-20089 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RASGRP2 Antibody - H00010235-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

RASGRP2 Antibody - H00010235-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RASGRP2 Antibody (1E5) - H00010235-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E5

Anti-RASGRP2 antibody produced in rabbit - HPA015667 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RASGRP2 antibody produced in rabbit - SAB1410074 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Monoclonal Anti-RASGRP2 antibody produced in mouse - WH0010235M9 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D8

Anti-RASGRP2, (N-terminal) antibody produced in rabbit - SAB2104344 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-RASGRP2 antibody produced in mouse - SAB1404802 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E5

RASGRP2 antibody - N-terminal region (ARP58820_P050) - ARP58820_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RASGRP2-Antibody-N-term - AP12183a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

RASGRP2-Antibody-monoclonal-M09 - AT3579a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D8

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