ATP7A

Gene Symbol ATP7A
Entrez Gene 538
Alt Symbol DSMAX, MK, MNK, SMAX3
Species Human
Gene Type protein-coding
Description ATPase, Cu++ transporting, alpha polypeptide
Other Description Cu++-transporting P-type ATPase|Menkes disease-associated protein|copper pump 1|copper-transporting ATPase 1
Swissprots O00227 Q9BYY8 B1AT72 O00745 Q04656
Accessions AAA96010 AAG47452 CAB08160 CAB08162 CAB94714 CBL93959 EAW98605 EAW98606 Q04656 AB117973 BAC82353 AB208828 BAD92065 AK096667 AK299449 BAG61422 BC156437 AAI56438 BP364137 BU753163 BX503903 CD299174 DB164588 L06133 AAA35580 L06476 AAA16974 NM_000052 NP_000043 NM_001282224 NP_001269153 NR_104109
Function May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Subcellular Location Isoform 5: Endoplasmic reticulum.
Tissue Specificity Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines.
Top Pathways Mineral absorption

ATP7A CRISPR/Cas9 KO Plasmid (h) - sc-402387 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A HDR Plasmid (h) - sc-402387-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A Double Nickase Plasmid (h) - sc-402387-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A Double Nickase Plasmid (h2) - sc-402387-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A CRISPR Activation Plasmid (h) - sc-402387-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A CRISPR Activation Plasmid (h2) - sc-402387-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A Lentiviral Activation Particles (h) - sc-402387-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A Lentiviral Activation Particles (h2) - sc-402387-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ATP7A siRNA (h) - sc-105107 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ATP7A shRNA Plasmid (h) - sc-105107-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ATP7A shRNA (h) Lentiviral Particles - sc-105107-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ATP7A RNAi - H00000538-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU116111 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3739 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3739 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ATP7A siRNA (Human) - CRH0372 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ATP7A - MBS8224492 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ATP7A (NM_000052.5) - SHH243250 from Creative biogene

Category siRNA
Species Reactivities Human

Human ATP7A siRNA - orb260874 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ATP7A shRNA Plasmid (Human) - CHH0372 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ATP7A miRNA 3'UTR clone - MiUTR4H-TG10651 from Creative biogene

Species Reactivities Human
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