| Gene Symbol |
MADCAM1
|
| Entrez Gene |
8174
|
| Alt Symbol |
MACAM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mucosal vascular addressin cell adhesion molecule 1
|
| Other Description |
MAdCAM-1|hMAdCAM-1|mucosal addressin cell adhesion molecule 1|mucosal addressin cell adhesion molecule-1
|
| Swissprots |
Q5UGI7 A5PKV4 O60222 O75867 B2RPL9 Q13477
|
| Accessions |
AAC51354 AAC62844 EAW61194 EAW61195 Q13477 AK092211 AY732484 AAV33123 AY819760 AAV68345 BC136408 AAI36409 BC137506 AAI37507 BC137507 AAI37508 BC142629 AAI42630 BC144065 AAI44066 DB323303 DQ076657 AAY82472 U43628 AAB02194 U82483 AAC13661 NM_130760 NP_570116 NM_130762 NP_570118
|
| Function |
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. {ECO:0000269|PubMed:8609404, ECO:0000269|PubMed:8989586}.
|
| Top Pathways |
Cell adhesion molecules (CAMs), Intestinal immune network for IgA production
|