| Gene Symbol |
Mbl1
|
| Entrez Gene |
17194
|
| Alt Symbol |
MBL-A, MBP-A, S-MBP
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mannose-binding lectin (protein A) 1
|
| Other Description |
mannan-binding protein|mannose binding lectin (A)|mannose binding lectin, serum (A)|mannose-binding protein A|ra-reactive factor polysaccharide-binding component p28B|raRF p28B
|
| Swissprots |
Q0P6H1 P39039
|
| Accessions |
AAA82009 EDL24920 P39039 AK034788 BC012245 AAH12245 BC021762 AAH21762 D11441 BAA02006 S42292 AAB19342 XM_006518669 XP_006518732 NM_010775 NP_034905
|
| Function |
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Top Pathways |
Complement and coagulation cascades, Phagosome, Staphylococcus aureus infection
|