| Gene Symbol |
Grm5
|
| Entrez Gene |
24418
|
| Alt Symbol |
mGluR5, mGlur5
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 5
|
| Other Description |
metabotropic glutamate receptor (mGluR5)|metabotropic glutamate receptor 5|metabotropic glutamate receptor 5b
|
| Swissprots |
P31424
|
| Accessions |
EDM18590 EDM18591 P31424 D10891 BAA01711 EU559292 ACB45671 XM_006229659 XP_006229721 NM_017012 NP_058708
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:1320017, ECO:0000269|PubMed:21795692}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:1320017}; Multi-pass membrane protein {ECO:0000269|PubMed:1320017}.
|
| Tissue Specificity |
Widely distributed in neuronal cells of the central nervous system. {ECO:0000269|PubMed:1320017, ECO:0000269|PubMed:21795692}.
|
| Top Pathways |
Gap junction, Long-term potentiation, Huntington's disease, Calcium signaling pathway, Glutamatergic synapse
|