Gene Symbol | RAB38 |
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Entrez Gene | 23682 |
Alt Symbol | NY-MEL-1, rrGTPbp |
Species | Human |
Gene Type | protein-coding |
Description | RAB38, member RAS oncogene family |
Other Description | Rab-related GTP-binding protein|melanoma antigen NY-MEL-1|ras-related protein Rab-38 |
Swissprots | P57729 Q53XK7 |
Accessions | ABA03166 EAW59365 EAW59366 P57729 AF136172 AAP97262 AF235022 AAG30731 AL546159 BC015808 AAH15808 BT009842 AAP88844 DQ891126 ABM82052 DQ894305 ABM85231 NM_022337 NP_071732 |
Function | May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000250|UniProtKB:Q8QZZ8, ECO:0000269|PubMed:21255211}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. |
Tissue Specificity | Expressed in melanocytes. |
Rab 38 CRISPR/Cas9 KO Plasmid (h) - sc-404742 from Santa Cruz Biotechnology
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Rab 38 HDR Plasmid (h) - sc-404742-HDR from Santa Cruz Biotechnology
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Rab 38 Double Nickase Plasmid (h) - sc-404742-NIC from Santa Cruz Biotechnology
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Rab 38 Double Nickase Plasmid (h2) - sc-404742-NIC-2 from Santa Cruz Biotechnology
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Rab 38 CRISPR Activation Plasmid (h) - sc-404742-ACT from Santa Cruz Biotechnology
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Rab 38 CRISPR Activation Plasmid (h2) - sc-404742-ACT-2 from Santa Cruz Biotechnology
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Rab 38 Lentiviral Activation Particles (h) - sc-404742-LAC from Santa Cruz Biotechnology
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Rab 38 Lentiviral Activation Particles (h2) - sc-404742-LAC-2 from Santa Cruz Biotechnology
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Rab 38 siRNA (h) - sc-96475 from Santa Cruz Biotechnology
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Rab 38 shRNA Plasmid (h) - sc-96475-SH from Santa Cruz Biotechnology
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Rab 38 shRNA (h) Lentiviral Particles - sc-96475-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036551 from Sigma-Aldrich
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MISSION® siRNA - SIHK1915 from Sigma-Aldrich
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MISSION® siRNA - SIHK1917 from Sigma-Aldrich
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MISSION® siRNA - SIHK1916 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17839 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17839 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05817 from Sigma-Aldrich
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RAB38 siRNA (Human) - CRH8436 from Cohesion Biosciences
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RAB38 RNAi - H00023682-R01 from Novus Biologicals
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RAB38 - MBS8208472 from MyBioSource
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shRNA set against Human RAB38 (NM_022337.2) - SHH388268 from Creative biogene
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Human RAB38 siRNA - orb268938 from Biorbyt
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RAB38 shRNA Plasmid (Human) - CHH8436 from Cohesion Biosciences
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RAB38 miRNA 3'UTR clone - MiUTR3H-08336 from Creative biogene
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