| Gene Symbol |
RAB38
|
| Entrez Gene |
23682
|
| Alt Symbol |
NY-MEL-1, rrGTPbp
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB38, member RAS oncogene family
|
| Other Description |
Rab-related GTP-binding protein|melanoma antigen NY-MEL-1|ras-related protein Rab-38
|
| Swissprots |
P57729 Q53XK7
|
| Accessions |
ABA03166 EAW59365 EAW59366 P57729 AF136172 AAP97262 AF235022 AAG30731 AL546159 BC015808 AAH15808 BT009842 AAP88844 DQ891126 ABM82052 DQ894305 ABM85231 NM_022337 NP_071732
|
| Function |
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000250|UniProtKB:Q8QZZ8, ECO:0000269|PubMed:21255211}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
|
| Tissue Specificity |
Expressed in melanocytes.
|