| Gene Symbol |
E2F2
|
| Entrez Gene |
1870
|
| Alt Symbol |
E2F-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 2
|
| Other Description |
transcription factor E2F2
|
| Swissprots |
Q14209 B2R9W1 Q7Z6H1
|
| Accessions |
AAM54044 EAW95055 EAW95056 EAW95057 EAW95058 Q14209 AF086395 AK092799 AK313939 BAG36658 BC007609 AAH07609 BC053676 AAH53676 BT019523 AAV38330 L22846 AAA16890 XM_005245748 XP_005245805 XM_005245749 XP_005245806 XM_011540868 XP_011539170 XM_011540869 XP_011539171 XM_011540870 XP_011539172 XM_011540871 XP_011539173 NM_004091 NP_004082
|
| Function |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
|
| Top Pathways |
MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma
|
