| Gene Symbol | E2F2 |
|---|---|
| Entrez Gene | 1870 |
| Alt Symbol | E2F-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 2 |
| Other Description | transcription factor E2F2 |
| Swissprots | Q14209 B2R9W1 Q7Z6H1 |
| Accessions | AAM54044 EAW95055 EAW95056 EAW95057 EAW95058 Q14209 AF086395 AK092799 AK313939 BAG36658 BC007609 AAH07609 BC053676 AAH53676 BT019523 AAV38330 L22846 AAA16890 XM_005245748 XP_005245805 XM_005245749 XP_005245806 XM_011540868 XP_011539170 XM_011540869 XP_011539171 XM_011540870 XP_011539172 XM_011540871 XP_011539173 NM_004091 NP_004082 |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples. |
| Top Pathways | MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma |