Gene Symbol | UGGT2 |
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Entrez Gene | 55757 |
Alt Symbol | HUGT2, UGCGL2, UGT2 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-glucose glycoprotein glucosyltransferase 2 |
Other Description | UDP--Glc:glycoprotein glucosyltransferase 2|UDP-Glc:glycoprotein glucosyltransferase 2|UDP-glucose ceramide glucosyltransferase-like 1|UDP-glucose ceramide glucosyltransferase-like 2|UDP-glucose:glycoprotein glucosyltransferase 2 |
Swissprots | Q9UFC4 Q8N5K0 A6NKL4 Q08AD0 Q5JQR8 Q9NYU1 |
Accessions | EAX08960 Q9NYU1 AF227906 AAF66233 AF339770 AK001735 BAA91869 AK021547 AL133051 CAB61378 BC017759 AAH17759 BC032302 AAH32302 BC067807 AAH67807 BC111021 AAI11022 BC125233 AAI25234 BC125234 AAI25235 XM_011521094 XP_011519396 XM_011521095 XP_011519397 XM_011521096 XP_011519398 XM_011521097 XP_011519399 XM_011521098 XP_011519400 XM_011521099 XP_011519401 XM_011521100 XP_011519402 XM_011521101 XP_011519403 XM_011521102 XP_011519404 XM_011521103 XP_011519405 XR_931617 NM_020121 NP_064506 |
Function | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}. |
Tissue Specificity | Higher levels in kidney, pancreas, heart, and skeletal muscle. {ECO:0000269|PubMed:10694380}. |
Top Pathways | Protein processing in endoplasmic reticulum |
HUGT2 CRISPR/Cas9 KO Plasmid (h) - sc-407545 from Santa Cruz Biotechnology
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HUGT2 HDR Plasmid (h) - sc-407545-HDR from Santa Cruz Biotechnology
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HUGT2 Double Nickase Plasmid (h) - sc-407545-NIC from Santa Cruz Biotechnology
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HUGT2 Double Nickase Plasmid (h2) - sc-407545-NIC-2 from Santa Cruz Biotechnology
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HUGT2 CRISPR Activation Plasmid (h) - sc-407545-ACT from Santa Cruz Biotechnology
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HUGT2 CRISPR Activation Plasmid (h2) - sc-407545-ACT-2 from Santa Cruz Biotechnology
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HUGT2 Lentiviral Activation Particles (h) - sc-407545-LAC from Santa Cruz Biotechnology
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HUGT2 Lentiviral Activation Particles (h2) - sc-407545-LAC-2 from Santa Cruz Biotechnology
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HUGT2 siRNA (h) - sc-75315 from Santa Cruz Biotechnology
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HUGT2 shRNA Plasmid (h) - sc-75315-SH from Santa Cruz Biotechnology
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HUGT2 shRNA (h) Lentiviral Particles - sc-75315-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22454 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22454 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01443 from Sigma-Aldrich
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UGGT2 siRNA (Human) - CRJ0895 from Cohesion Biosciences
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UGGT2 - MBS8212684 from MyBioSource
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Human UGGT2 siRNA - orb271396 from Biorbyt
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UGGT2 shRNA Plasmid (Human) - CHJ0895 from Cohesion Biosciences
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UGGT2 miRNA 3'UTR clone - MiUTR3H-08028 from Creative biogene
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