Gene Symbol | UGGT2 |
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Entrez Gene | 55757 |
Alt Symbol | HUGT2, UGCGL2, UGT2 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-glucose glycoprotein glucosyltransferase 2 |
Other Description | UDP--Glc:glycoprotein glucosyltransferase 2|UDP-Glc:glycoprotein glucosyltransferase 2|UDP-glucose ceramide glucosyltransferase-like 1|UDP-glucose ceramide glucosyltransferase-like 2|UDP-glucose:glycoprotein glucosyltransferase 2 |
Swissprots | Q9UFC4 Q8N5K0 A6NKL4 Q08AD0 Q5JQR8 Q9NYU1 |
Accessions | EAX08960 Q9NYU1 AF227906 AAF66233 AF339770 AK001735 BAA91869 AK021547 AL133051 CAB61378 BC017759 AAH17759 BC032302 AAH32302 BC067807 AAH67807 BC111021 AAI11022 BC125233 AAI25234 BC125234 AAI25235 XM_011521094 XP_011519396 XM_011521095 XP_011519397 XM_011521096 XP_011519398 XM_011521097 XP_011519399 XM_011521098 XP_011519400 XM_011521099 XP_011519401 XM_011521100 XP_011519402 XM_011521101 XP_011519403 XM_011521102 XP_011519404 XM_011521103 XP_011519405 XR_931617 NM_020121 NP_064506 |
Function | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}. |
Tissue Specificity | Higher levels in kidney, pancreas, heart, and skeletal muscle. {ECO:0000269|PubMed:10694380}. |
Top Pathways | Protein processing in endoplasmic reticulum |
Human UGCGL2 protein fragment - ab132777 from Abcam
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Human UGCGL2 protein fragment - ab127098 from Abcam
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UGGT2 Antibody Blocking Peptide - LS-E17664 from LifeSpan Bioscience
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UGGT2 Antibody Blocking Peptide - LS-E17665 from LifeSpan Bioscience
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Recombinant Human UGCGL2 Protein - H00055757-P01 from Novus Biologicals
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UGCGL2 Blocking Peptide - 33R-4422 from Fitzgerald
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UGCGL2 Blocking Peptide - 33R-4827 from Fitzgerald
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Human UGGT2 Protein - abx069599 from Abbexa
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UGCGL2 / UGT2 - H00055757-P01-10 from Acris Antibodies
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UGCGL2 / UGT2 - H00055757-P01-25 from Acris Antibodies
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UDP-Glucose Glycoprotein Glucosyltransferase 2 - 20-9355 from ARP American Research Products
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UGCGL2 fusion protein - Ag4356 from Proteintech Group
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UGCGL2 fusion protein - Ag4189 from Proteintech Group
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Recombinant Human UGCGL2, His-tagged - UGCGL2-3583H from Creative Biomart
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Recombinant UDP-Glucose Glycoprotein Glucosyltransferase 2 (UGGT2) - RPJ268Hu01 from Uscn Life Science Inc.
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Recombinant UDP-Glucose Glycoprotein Glucosyltransferase 2 (UGGT2) - RPJ268Hu01 from Cloud-clone
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Recombinant Human UDP-glucose:glycoprotein glucosyltransferase 2(UGGT2) ,partial - CSB-YP865182HU CSB-EP865182HU CSB-BP865182HU CSB-MP865182HU from Cusabio
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UDP-Glucose Glycoprotein Glucosyltransferase 2 (UGGT2) - RPU144284 from Biomatik
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UGCGL2 Protein - NBP2-13503PEP from Novus Biologicals
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UGGT2 Peptide, Human - M34GP17044H from Creative Peptides
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Recombinant UDP-Glucose Glycoprotein Glucosyltransferase 2 (UGGT2) - RPU44284 from Biomatik
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UGGT2 Recombinant Protein (OPCD07826) - OPCD07826 from Aviva Systems Biology
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Recombinant Human UGGT2 protein, His & S-tagged - UGGT2-1650H from Creative Biomart
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