| Gene Symbol |
tolC
|
| Entrez Gene |
947521
|
| Alt Symbol |
ECK3026, JW5503, colE1-i, mtcB, mukA, refI, toc, weeA
|
| Species |
Escherichia coli
|
| Gene Type |
protein-coding
|
| Description |
transport channel
|
| Other Description |
-
|
| Swissprots |
Q2M9G5 P02930
|
| Accessions |
AAC76071 NP_417507
|
| Function |
Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. {ECO:0000269|PubMed:11274125, ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:18955484, ECO:0000269|PubMed:23176499, ECO:0000269|PubMed:6337123}.
|
| Subcellular Location |
Cell outer membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229, ECO:0000269|PubMed:6337123, ECO:0000269|PubMed:9044294}; Multi-pass membrane protein {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229, ECO:0000269|PubMed:6337123, ECO:0000269|PubMed:9044294}.
|
| Top Pathways |
Bacterial secretion system, beta-Lactam resistance, Cationic antimicrobial peptide (CAMP) resistance
|