Gene Symbol | TIPIN |
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Entrez Gene | 54962 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | TIMELESS interacting protein |
Other Description | CSM3 homolog|TIMELESS-interacting protein |
Swissprots | Q9NWZ6 Q9BVW5 B2CW64 |
Accessions | ACB21044 EAW77762 EAW77763 Q9BVW5 AK000523 BAA91229 AK299233 BAG61265 BC000870 AAH00870 BK001386 DAA01365 BU596053 BU688750 XM_005254521 XP_005254578 XM_005254522 XP_005254579 XM_006720594 XP_006720657 XM_011521743 XP_011520045 NM_001289986 NP_001276915 NM_017858 NP_060328 |
Function | Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725}. |
Subcellular Location | Cytoplasm. Nucleus. |
Human TIPIN full length protein - ab162916 from Abcam
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Human TIPIN full length protein - ab171713 from Abcam
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TIPIN Antibody Blocking Peptide - LS-E6730 from LifeSpan Bioscience
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TIPIN Antibody Blocking Peptide - LS-E18271 from LifeSpan Bioscience
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TIPIN Antibody Blocking Peptide - LS-E18272 from LifeSpan Bioscience
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TIPIN Recombinant Protein - H00054962-P01 from Novus Biologicals
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Recombinant Human TIPIN Protein - NBP2-22868 from Novus Biologicals
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TIPIN-AntibodyN-term-Blocking-peptide - BP19596a from Abgent, a WuXi AppTec company
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TIPIN Blocking Peptide - 33R-8402 from Fitzgerald
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TIPIN Blocking Peptide - 33R-6186 from Fitzgerald
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TIPIN protein (His tag) - 80R-3048 from Fitzgerald
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TIPIN (1-301, His-tag) - AR51166PU-N from Acris Antibodies
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TIPIN (1-301, His-tag) - AR51166PU-S from Acris Antibodies
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TIPIN - H00054962-P01-10 from Acris Antibodies
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TIPIN - H00054962-P01-25 from Acris Antibodies
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TIPIN control peptide - AP10337CP-N from Acris Antibodies
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TIPIN, 1-301aa, Human, His tag, E.coli - 01-P2342 from ARP American Research Products
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TIPIN fusion protein - ag2595 from Proteintech Group
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TIPIN, 1-301aa, Human, His tag, E.coli - GWB-ATG525 from Genway Biotech
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Recombinant Human TIPIN, His-tagged - TIPIN-2342H from Creative Biomart
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Recombinant Human TIMELESS-interacting protein(TIPIN) - CSB-YP880115HU CSB-EP880115HU CSB-BP880115HU CSB-MP880115HU from Cusabio
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TIPIN, 1-301aa, Human, His tag, E.coli - ATGP2342 from ATGen
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TIPIN (full length, N-term HIS tag) - TP760014 from Acris Antibodies
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TIPIN Recombinant Protein Antigen - NBP2-38860PEP from Novus Biologicals
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Human TIPIN protein - orb260143 from Biorbyt
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