Gene Symbol | MC5R |
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Entrez Gene | 4161 |
Alt Symbol | MC2 |
Species | Human |
Gene Type | protein-coding |
Description | melanocortin 5 receptor |
Other Description | melanocortin receptor 5|melanocortin-5 receptor |
Swissprots | Q502V1 B0YJ34 P33032 |
Accessions | AAA59566 AAB60376 AAP23196 ACA06012 CAA80962 EAX01504 P33032 BC069153 AAH69153 BC069545 AAH69545 BC095531 AAH95531 NM_005913 NP_005904 |
Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in the brain but not in the melanoma cells. |
Top Pathways | Neuroactive ligand-receptor interaction |
MC5-R CRISPR/Cas9 KO Plasmid (h) - sc-403844 from Santa Cruz Biotechnology
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MC5-R HDR Plasmid (h) - sc-403844-HDR from Santa Cruz Biotechnology
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MC5-R Double Nickase Plasmid (h) - sc-403844-NIC from Santa Cruz Biotechnology
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MC5-R Double Nickase Plasmid (h2) - sc-403844-NIC-2 from Santa Cruz Biotechnology
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MC5-R CRISPR Activation Plasmid (h) - sc-403844-ACT from Santa Cruz Biotechnology
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MC5-R CRISPR Activation Plasmid (h2) - sc-403844-ACT-2 from Santa Cruz Biotechnology
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MC5-R Lentiviral Activation Particles (h) - sc-403844-LAC from Santa Cruz Biotechnology
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MC5-R Lentiviral Activation Particles (h2) - sc-403844-LAC-2 from Santa Cruz Biotechnology
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MC5-R siRNA (h) - sc-35875 from Santa Cruz Biotechnology
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MC5-R shRNA Plasmid (h) - sc-35875-SH from Santa Cruz Biotechnology
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MC5-R shRNA (h) Lentiviral Particles - sc-35875-V from Santa Cruz Biotechnology
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Melanocortin-5 R/MC5R RNAi - H00004161-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN13097 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13097 from Sigma-Aldrich
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MC5R siRNA (Human) - CRH2833 from Cohesion Biosciences
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shRNA set against Human MC5R (NM_005913.2) - SHH339075 from Creative biogene
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Human MC5R siRNA - orb263335 from Biorbyt
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MC5R shRNA Plasmid (Human) - CHH2833 from Cohesion Biosciences
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MC5R miRNA 3'UTR clone - MiUTR4H-TG11715 from Creative biogene
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