Gene Symbol | FCER1A |
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Entrez Gene | 2205 |
Alt Symbol | FCE1A, FcERI |
Species | Human |
Gene Type | protein-coding |
Description | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
Other Description | Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|high affinity immunoglobulin epsilon receptor subunit alpha|igE Fc receptor subunit alpha|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide |
Swissprots | P12319 |
Accessions | AAA16115 BAB84120 CAA01564 CAA82702 CAN36268 EAW52789 P12319 BC005912 AAH05912 BC015185 BC015195 AAH15195 DQ893131 ABM84057 DQ896411 ABM87410 DQ896467 ABM87466 J03605 AAA36204 X06948 CAA30025 NM_002001 NP_001992 |
Function | Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Fc epsilon RI signaling pathway, Asthma, Sphingolipid signaling pathway |
Fc ε RIα siRNA (h) - sc-45258 from Santa Cruz Biotechnology
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Fc ε RIα shRNA Plasmid (h) - sc-45258-SH from Santa Cruz Biotechnology
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Fc ε RIα shRNA (h) Lentiviral Particles - sc-45258-V from Santa Cruz Biotechnology
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Fc epsilon RI RNAi - H00002205-R01V from Novus Biologicals
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Fc epsilon RI RNAi - H00002205-R02 from Novus Biologicals
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MISSION® esiRNA - EHU014371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8581 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02517 from Sigma-Aldrich
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FCER1A siRNA (Human) - CRH1540 from Cohesion Biosciences
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FCER1A - MBS8200560 from MyBioSource
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shRNA set against Human FCER1A (NM_002001.3) - SHH293621 from Creative biogene
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Human FCER1A siRNA - orb262042 from Biorbyt
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FCER1A shRNA Plasmid (Human) - CHH1540 from Cohesion Biosciences
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