| Gene Symbol |
lpxD
|
| Entrez Gene |
944882
|
| Alt Symbol |
ECK0178, JW0174, firA, omsA, ssc
|
| Species |
Escherichia coli
|
| Gene Type |
protein-coding
|
| Description |
UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase
|
| Other Description |
-
|
| Swissprots |
P21645
|
| Accessions |
AAC73290 NP_414721
|
| Function |
Catalyzes the N-acylation of UDP-3-O- (hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions. {ECO:0000269|PubMed:19655786, ECO:0000269|PubMed:8444173}.
|
| Top Pathways |
Lipopolysaccharide biosynthesis
|