| Gene Symbol | MOCS3-2 |
|---|---|
| Entrez Gene | 100191959 |
| Alt Symbol | UBA4-2 |
| Species | Corn |
| Gene Type | protein-coding |
| Description | adenylyltransferase and sulfurtransferase MOCS3 2 |
| Other Description | adenylyltransferase and sulfurtransferase MOCS3-2|molybdenum cofactor synthesis protein 3 2 |
| Swissprots | B4FAT0 |
| Accessions | B4FAT0 BT034218 ACF79223 BT039186 ACF84191 XM_008678232 XP_008676454 XM_008678233 XP_008676455 XM_008678234 XP_008676456 XM_008678235 XP_008676457 XM_008678236 XP_008676458 XM_008678237 XP_008676459 NM_001137383 NP_001130855 |
| Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049}. |
| Top Pathways | Sulfur relay system |